Stereoselective Transformation of Chiral Amine: Novel Approach to the Synthesis of Optically Active Intermediate of Silodosin
- 作者: Buchi Reddy R.1, More K.1, Gupta L.1
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隶属关系:
- Ipca Laboratories Ltd., Chemical Research Division, Kandivali Industrial Estate
- 期: 卷 51, 编号 6 (2017)
- 页面: 494-499
- 栏目: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244672
- DOI: https://doi.org/10.1007/s11094-017-1641-0
- ID: 244672
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详细
A novel, economical and highly efficient synthetic approach has been developed for the synthesis of silodosin optically active intermediate and its application to facile preparation of silodosin parent compound. It involves stereoselective inversion of unwanted isomer of the silodosin key chiral amine intermediate via the nucleophilic substitution reaction with azide ion on (a) N,N-ditosylimide derivative and (b) 2,4,6-triphenyl pyridinium cation.
作者简介
R. Buchi Reddy
Ipca Laboratories Ltd., Chemical Research Division, Kandivali Industrial Estate
Email: kishor.more@ipca.com
印度, Kandivali (W)., Mumbai, 400067
Kishor More
Ipca Laboratories Ltd., Chemical Research Division, Kandivali Industrial Estate
编辑信件的主要联系方式.
Email: kishor.more@ipca.com
印度, Kandivali (W)., Mumbai, 400067
Leena Gupta
Ipca Laboratories Ltd., Chemical Research Division, Kandivali Industrial Estate
Email: kishor.more@ipca.com
印度, Kandivali (W)., Mumbai, 400067