Stereoselective Transformation of Chiral Amine: Novel Approach to the Synthesis of Optically Active Intermediate of Silodosin
- Авторлар: Buchi Reddy R.1, More K.1, Gupta L.1
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Мекемелер:
- Ipca Laboratories Ltd., Chemical Research Division, Kandivali Industrial Estate
- Шығарылым: Том 51, № 6 (2017)
- Беттер: 494-499
- Бөлім: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244672
- DOI: https://doi.org/10.1007/s11094-017-1641-0
- ID: 244672
Дәйексөз келтіру
Аннотация
A novel, economical and highly efficient synthetic approach has been developed for the synthesis of silodosin optically active intermediate and its application to facile preparation of silodosin parent compound. It involves stereoselective inversion of unwanted isomer of the silodosin key chiral amine intermediate via the nucleophilic substitution reaction with azide ion on (a) N,N-ditosylimide derivative and (b) 2,4,6-triphenyl pyridinium cation.
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Авторлар туралы
R. Buchi Reddy
Ipca Laboratories Ltd., Chemical Research Division, Kandivali Industrial Estate
Email: kishor.more@ipca.com
Үндістан, Kandivali (W)., Mumbai, 400067
Kishor More
Ipca Laboratories Ltd., Chemical Research Division, Kandivali Industrial Estate
Хат алмасуға жауапты Автор.
Email: kishor.more@ipca.com
Үндістан, Kandivali (W)., Mumbai, 400067
Leena Gupta
Ipca Laboratories Ltd., Chemical Research Division, Kandivali Industrial Estate
Email: kishor.more@ipca.com
Үндістан, Kandivali (W)., Mumbai, 400067