Stereoselective Transformation of Chiral Amine: Novel Approach to the Synthesis of Optically Active Intermediate of Silodosin
- Authors: Buchi Reddy R.1, More K.R.1, Gupta L.1
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Affiliations:
- Ipca Laboratories Ltd., Chemical Research Division, Kandivali Industrial Estate
- Issue: Vol 51, No 6 (2017)
- Pages: 494-499
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244672
- DOI: https://doi.org/10.1007/s11094-017-1641-0
- ID: 244672
Cite item
Abstract
A novel, economical and highly efficient synthetic approach has been developed for the synthesis of silodosin optically active intermediate and its application to facile preparation of silodosin parent compound. It involves stereoselective inversion of unwanted isomer of the silodosin key chiral amine intermediate via the nucleophilic substitution reaction with azide ion on (a) N,N-ditosylimide derivative and (b) 2,4,6-triphenyl pyridinium cation.
Keywords
About the authors
R. Buchi Reddy
Ipca Laboratories Ltd., Chemical Research Division, Kandivali Industrial Estate
Email: kishor.more@ipca.com
India, Kandivali (W)., Mumbai, 400067
Kishor R. More
Ipca Laboratories Ltd., Chemical Research Division, Kandivali Industrial Estate
Author for correspondence.
Email: kishor.more@ipca.com
India, Kandivali (W)., Mumbai, 400067
Leena Gupta
Ipca Laboratories Ltd., Chemical Research Division, Kandivali Industrial Estate
Email: kishor.more@ipca.com
India, Kandivali (W)., Mumbai, 400067