Stereoselective Transformation of Chiral Amine: Novel Approach to the Synthesis of Optically Active Intermediate of Silodosin
- Авторы: Buchi Reddy R.1, More K.1, Gupta L.1
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Учреждения:
- Ipca Laboratories Ltd., Chemical Research Division, Kandivali Industrial Estate
- Выпуск: Том 51, № 6 (2017)
- Страницы: 494-499
- Раздел: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244672
- DOI: https://doi.org/10.1007/s11094-017-1641-0
- ID: 244672
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Аннотация
A novel, economical and highly efficient synthetic approach has been developed for the synthesis of silodosin optically active intermediate and its application to facile preparation of silodosin parent compound. It involves stereoselective inversion of unwanted isomer of the silodosin key chiral amine intermediate via the nucleophilic substitution reaction with azide ion on (a) N,N-ditosylimide derivative and (b) 2,4,6-triphenyl pyridinium cation.
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Об авторах
R. Buchi Reddy
Ipca Laboratories Ltd., Chemical Research Division, Kandivali Industrial Estate
Email: kishor.more@ipca.com
Индия, Kandivali (W)., Mumbai, 400067
Kishor More
Ipca Laboratories Ltd., Chemical Research Division, Kandivali Industrial Estate
Автор, ответственный за переписку.
Email: kishor.more@ipca.com
Индия, Kandivali (W)., Mumbai, 400067
Leena Gupta
Ipca Laboratories Ltd., Chemical Research Division, Kandivali Industrial Estate
Email: kishor.more@ipca.com
Индия, Kandivali (W)., Mumbai, 400067