1-Substituted 2-Benzylaminobenzimidazoles with Phenyl Methoxyls: Synthesis, Computer Prediction, and Pharmacological Activity
- Авторы: Zhukovskaya O.1, Anisimova V.1, Spasov A.2,3,4, Vasil’ev P.2,3, Kosolapov V.2,3, Kucheryavenko A.2, Gurova N.2, Naumenko L.2, Kuznetsova V.3, Sorotskii D.3, Solov’eva O.2, Reznikov E.2, Gurova V.2, Sirotenko V.2
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Учреждения:
- Research Institute of Physical and Organic Chemistry, Southern Federal University
- Volgograd State Medical University
- Research Institute of Pharmacology, Volgograd State Medical University
- Volgograd Medical Scientific Center, Russian Academy of Medical Sciences
- Выпуск: Том 49, № 11 (2016)
- Страницы: 735-742
- Раздел: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244283
- DOI: https://doi.org/10.1007/s11094-016-1362-9
- ID: 244283
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Аннотация
Condensation of 1-substituted 2-aminobenzimidazoles with aromatic aldehydes produced the corresponding azomethines, reduction of which by sodium borohydride afforded 1-substituted 2-benzylaminobenzimidazoles. The Microcosm information technology (IT) tool was used to assess in silico the potential for antiarrhythmic, antiaggregant, antioxidant, hemorheologic, and antiglycating activity in this series of compounds. Pharmacological screening identified which of the synthesized compounds were active. It was shown that the computer predictions correlated with the experimental data.
Об авторах
O. Zhukovskaya
Research Institute of Physical and Organic Chemistry, Southern Federal University
Автор, ответственный за переписку.
Email: zhukowskaia.ol@yandex.ru
Россия, Rostov-on-Don
V. Anisimova
Research Institute of Physical and Organic Chemistry, Southern Federal University
Email: zhukowskaia.ol@yandex.ru
Россия, Rostov-on-Don
A. Spasov
Volgograd State Medical University; Research Institute of Pharmacology, Volgograd State Medical University; Volgograd Medical Scientific Center, Russian Academy of Medical Sciences
Email: zhukowskaia.ol@yandex.ru
Россия, Volgograd; Volgograd; Volgograd
P. Vasil’ev
Volgograd State Medical University; Research Institute of Pharmacology, Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Россия, Volgograd; Volgograd
V. Kosolapov
Volgograd State Medical University; Research Institute of Pharmacology, Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Россия, Volgograd; Volgograd
A. Kucheryavenko
Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Россия, Volgograd
N. Gurova
Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Россия, Volgograd
L. Naumenko
Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Россия, Volgograd
V. Kuznetsova
Research Institute of Pharmacology, Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Россия, Volgograd
D. Sorotskii
Research Institute of Pharmacology, Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Россия, Volgograd
O. Solov’eva
Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Россия, Volgograd
E. Reznikov
Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Россия, Volgograd
V. Gurova
Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Россия, Volgograd
V. Sirotenko
Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Россия, Volgograd