1-Substituted 2-Benzylaminobenzimidazoles with Phenyl Methoxyls: Synthesis, Computer Prediction, and Pharmacological Activity
- Авторлар: Zhukovskaya O.1, Anisimova V.1, Spasov A.2,3,4, Vasil’ev P.2,3, Kosolapov V.2,3, Kucheryavenko A.2, Gurova N.2, Naumenko L.2, Kuznetsova V.3, Sorotskii D.3, Solov’eva O.2, Reznikov E.2, Gurova V.2, Sirotenko V.2
-
Мекемелер:
- Research Institute of Physical and Organic Chemistry, Southern Federal University
- Volgograd State Medical University
- Research Institute of Pharmacology, Volgograd State Medical University
- Volgograd Medical Scientific Center, Russian Academy of Medical Sciences
- Шығарылым: Том 49, № 11 (2016)
- Беттер: 735-742
- Бөлім: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244283
- DOI: https://doi.org/10.1007/s11094-016-1362-9
- ID: 244283
Дәйексөз келтіру
Аннотация
Condensation of 1-substituted 2-aminobenzimidazoles with aromatic aldehydes produced the corresponding azomethines, reduction of which by sodium borohydride afforded 1-substituted 2-benzylaminobenzimidazoles. The Microcosm information technology (IT) tool was used to assess in silico the potential for antiarrhythmic, antiaggregant, antioxidant, hemorheologic, and antiglycating activity in this series of compounds. Pharmacological screening identified which of the synthesized compounds were active. It was shown that the computer predictions correlated with the experimental data.
Авторлар туралы
O. Zhukovskaya
Research Institute of Physical and Organic Chemistry, Southern Federal University
Хат алмасуға жауапты Автор.
Email: zhukowskaia.ol@yandex.ru
Ресей, Rostov-on-Don
V. Anisimova
Research Institute of Physical and Organic Chemistry, Southern Federal University
Email: zhukowskaia.ol@yandex.ru
Ресей, Rostov-on-Don
A. Spasov
Volgograd State Medical University; Research Institute of Pharmacology, Volgograd State Medical University; Volgograd Medical Scientific Center, Russian Academy of Medical Sciences
Email: zhukowskaia.ol@yandex.ru
Ресей, Volgograd; Volgograd; Volgograd
P. Vasil’ev
Volgograd State Medical University; Research Institute of Pharmacology, Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Ресей, Volgograd; Volgograd
V. Kosolapov
Volgograd State Medical University; Research Institute of Pharmacology, Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Ресей, Volgograd; Volgograd
A. Kucheryavenko
Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Ресей, Volgograd
N. Gurova
Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Ресей, Volgograd
L. Naumenko
Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Ресей, Volgograd
V. Kuznetsova
Research Institute of Pharmacology, Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Ресей, Volgograd
D. Sorotskii
Research Institute of Pharmacology, Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Ресей, Volgograd
O. Solov’eva
Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Ресей, Volgograd
E. Reznikov
Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Ресей, Volgograd
V. Gurova
Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Ресей, Volgograd
V. Sirotenko
Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Ресей, Volgograd