1-Substituted 2-Benzylaminobenzimidazoles with Phenyl Methoxyls: Synthesis, Computer Prediction, and Pharmacological Activity

O. N. Zhukovskaya; V. A. Anisimova; A. A. Spasov; P. M. Vasil’ev; V. A. Kosolapov; A. F. Kucheryavenko; N. A. Gurova; L. V. Naumenko; V. A. Kuznetsova; D. V. Sorotskii; O. A. Solov’eva; E. V. Reznikov; V. V. Gurova; V. S. Sirotenko

doi:10.1007/s11094-016-1362-9

1-Substituted 2-Benzylaminobenzimidazoles with Phenyl Methoxyls: Synthesis, Computer Prediction, and Pharmacological Activity

Authors: Zhukovskaya O.N.¹, Anisimova V.A.¹, Spasov A.A.²^,3^,4, Vasil’ev P.M.²^,3, Kosolapov V.A.²^,3, Kucheryavenko A.F.², Gurova N.A.², Naumenko L.V.², Kuznetsova V.A.³, Sorotskii D.V.³, Solov’eva O.A.², Reznikov E.V.², Gurova V.V.², Sirotenko V.S.²
Affiliations:
1. Research Institute of Physical and Organic Chemistry, Southern Federal University
2. Volgograd State Medical University
3. Research Institute of Pharmacology, Volgograd State Medical University
4. Volgograd Medical Scientific Center, Russian Academy of Medical Sciences
Issue: Vol 49, No 11 (2016)
Pages: 735-742
Section: Article
URL: https://journals.rcsi.science/0091-150X/article/view/244283
DOI: https://doi.org/10.1007/s11094-016-1362-9
ID: 244283

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Abstract

Condensation of 1-substituted 2-aminobenzimidazoles with aromatic aldehydes produced the corresponding azomethines, reduction of which by sodium borohydride afforded 1-substituted 2-benzylaminobenzimidazoles. The Microcosm information technology (IT) tool was used to assess in silico the potential for antiarrhythmic, antiaggregant, antioxidant, hemorheologic, and antiglycating activity in this series of compounds. Pharmacological screening identified which of the synthesized compounds were active. It was shown that the computer predictions correlated with the experimental data.

Keywords

1-substituted 2-benzylaminobenzimidazoles, synthesis, Microcosm IT tool, in silico search, antiarrhythmic, antiaggregant, antioxidant, hemorheologic, and antiglycating activity, experimental study

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1-Substituted 2-Benzylaminobenzimidazoles with Phenyl Methoxyls: Synthesis, Computer Prediction, and Pharmacological Activity

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