Enviar artigo por via de e-mail 1-Substituted 2-Benzylaminobenzimidazoles with Phenyl Methoxyls: Synthesis, Computer Prediction, and Pharmacological Activity
- Autores: Zhukovskaya O.1, Anisimova V.1, Spasov A.2,3,4, Vasil’ev P.2,3, Kosolapov V.2,3, Kucheryavenko A.2, Gurova N.2, Naumenko L.2, Kuznetsova V.3, Sorotskii D.3, Solov’eva O.2, Reznikov E.2, Gurova V.2, Sirotenko V.2
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Afiliações:
- Research Institute of Physical and Organic Chemistry, Southern Federal University
- Volgograd State Medical University
- Research Institute of Pharmacology, Volgograd State Medical University
- Volgograd Medical Scientific Center, Russian Academy of Medical Sciences
- Edição: Volume 49, Nº 11 (2016)
- Páginas: 735-742
- Seção: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244283
- DOI: https://doi.org/10.1007/s11094-016-1362-9
- ID: 244283
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Resumo
Condensation of 1-substituted 2-aminobenzimidazoles with aromatic aldehydes produced the corresponding azomethines, reduction of which by sodium borohydride afforded 1-substituted 2-benzylaminobenzimidazoles. The Microcosm information technology (IT) tool was used to assess in silico the potential for antiarrhythmic, antiaggregant, antioxidant, hemorheologic, and antiglycating activity in this series of compounds. Pharmacological screening identified which of the synthesized compounds were active. It was shown that the computer predictions correlated with the experimental data.
Sobre autores
O. Zhukovskaya
Research Institute of Physical and Organic Chemistry, Southern Federal University
Autor responsável pela correspondência
Email: zhukowskaia.ol@yandex.ru
Rússia, Rostov-on-Don
V. Anisimova
Research Institute of Physical and Organic Chemistry, Southern Federal University
Email: zhukowskaia.ol@yandex.ru
Rússia, Rostov-on-Don
A. Spasov
Volgograd State Medical University; Research Institute of Pharmacology, Volgograd State Medical University; Volgograd Medical Scientific Center, Russian Academy of Medical Sciences
Email: zhukowskaia.ol@yandex.ru
Rússia, Volgograd; Volgograd; Volgograd
P. Vasil’ev
Volgograd State Medical University; Research Institute of Pharmacology, Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Rússia, Volgograd; Volgograd
V. Kosolapov
Volgograd State Medical University; Research Institute of Pharmacology, Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Rússia, Volgograd; Volgograd
A. Kucheryavenko
Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Rússia, Volgograd
N. Gurova
Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Rússia, Volgograd
L. Naumenko
Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Rússia, Volgograd
V. Kuznetsova
Research Institute of Pharmacology, Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Rússia, Volgograd
D. Sorotskii
Research Institute of Pharmacology, Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Rússia, Volgograd
O. Solov’eva
Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Rússia, Volgograd
E. Reznikov
Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Rússia, Volgograd
V. Gurova
Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Rússia, Volgograd
V. Sirotenko
Volgograd State Medical University
Email: zhukowskaia.ol@yandex.ru
Rússia, Volgograd
