An Improved Method for the Synthesis of the of Indole[2,3-a]Pyrrolo[3,4-c]Carbazole-5,6-Dione N-Glycosides and their Cytotoxic Activity
- Autores: Éktova L.1, Goryunova O.1, Eremina V.1, Tikhonova N.1, Medvedeva L.1
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Afiliações:
- N. N. Blokhin Oncology National Medical Research Center, Ministry of Health of the Russian Federation
- Edição: Volume 53, Nº 7 (2019)
- Páginas: 604-609
- Seção: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245895
- DOI: https://doi.org/10.1007/s11094-019-02046-4
- ID: 245895
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Resumo
Use of formylindolylacetic acid as a reagent at the stage of preparing the glycosides of bis(indolyl)furan-2,5-diones and dioxane as solvent increased yields from 5 – 10% to 60 – 63%, decreased the duration of the reaction from 6 h to 2 h, and significantly simplified extraction of products adequate for use at the next stage of photochemical oxidation to furancarbazole derivatives. New data are presented on the cytotoxic activity of the indocarbazole N-glycosides synthesized here, covering a wide range of cell structures and giving a more complete view of the antiproliferative properties of the compounds synthesized.
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Sobre autores
L. Éktova
N. N. Blokhin Oncology National Medical Research Center, Ministry of Health of the Russian Federation
Autor responsável pela correspondência
Email: ektova@ronc.ru
Rússia, 24 Kashirskoe Chaussee, Moscow, 115478
O. Goryunova
N. N. Blokhin Oncology National Medical Research Center, Ministry of Health of the Russian Federation
Email: ektova@ronc.ru
Rússia, 24 Kashirskoe Chaussee, Moscow, 115478
V. Eremina
N. N. Blokhin Oncology National Medical Research Center, Ministry of Health of the Russian Federation
Email: ektova@ronc.ru
Rússia, 24 Kashirskoe Chaussee, Moscow, 115478
N. Tikhonova
N. N. Blokhin Oncology National Medical Research Center, Ministry of Health of the Russian Federation
Email: ektova@ronc.ru
Rússia, 24 Kashirskoe Chaussee, Moscow, 115478
L. Medvedeva
N. N. Blokhin Oncology National Medical Research Center, Ministry of Health of the Russian Federation
Email: ektova@ronc.ru
Rússia, 24 Kashirskoe Chaussee, Moscow, 115478