An Improved Method for the Synthesis of the of Indole[2,3-a]Pyrrolo[3,4-c]Carbazole-5,6-Dione N-Glycosides and their Cytotoxic Activity
- Авторлар: Éktova L.1, Goryunova O.1, Eremina V.1, Tikhonova N.1, Medvedeva L.1
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Мекемелер:
- N. N. Blokhin Oncology National Medical Research Center, Ministry of Health of the Russian Federation
- Шығарылым: Том 53, № 7 (2019)
- Беттер: 604-609
- Бөлім: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245895
- DOI: https://doi.org/10.1007/s11094-019-02046-4
- ID: 245895
Дәйексөз келтіру
Аннотация
Use of formylindolylacetic acid as a reagent at the stage of preparing the glycosides of bis(indolyl)furan-2,5-diones and dioxane as solvent increased yields from 5 – 10% to 60 – 63%, decreased the duration of the reaction from 6 h to 2 h, and significantly simplified extraction of products adequate for use at the next stage of photochemical oxidation to furancarbazole derivatives. New data are presented on the cytotoxic activity of the indocarbazole N-glycosides synthesized here, covering a wide range of cell structures and giving a more complete view of the antiproliferative properties of the compounds synthesized.
Негізгі сөздер
Авторлар туралы
L. Éktova
N. N. Blokhin Oncology National Medical Research Center, Ministry of Health of the Russian Federation
Хат алмасуға жауапты Автор.
Email: ektova@ronc.ru
Ресей, 24 Kashirskoe Chaussee, Moscow, 115478
O. Goryunova
N. N. Blokhin Oncology National Medical Research Center, Ministry of Health of the Russian Federation
Email: ektova@ronc.ru
Ресей, 24 Kashirskoe Chaussee, Moscow, 115478
V. Eremina
N. N. Blokhin Oncology National Medical Research Center, Ministry of Health of the Russian Federation
Email: ektova@ronc.ru
Ресей, 24 Kashirskoe Chaussee, Moscow, 115478
N. Tikhonova
N. N. Blokhin Oncology National Medical Research Center, Ministry of Health of the Russian Federation
Email: ektova@ronc.ru
Ресей, 24 Kashirskoe Chaussee, Moscow, 115478
L. Medvedeva
N. N. Blokhin Oncology National Medical Research Center, Ministry of Health of the Russian Federation
Email: ektova@ronc.ru
Ресей, 24 Kashirskoe Chaussee, Moscow, 115478