An Improved Method for the Synthesis of the of Indole[2,3-a]Pyrrolo[3,4-c]Carbazole-5,6-Dione N-Glycosides and their Cytotoxic Activity
- Authors: Éktova L.V.1, Goryunova O.V.1, Eremina V.A.1, Tikhonova N.I.1, Medvedeva L.A.1
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Affiliations:
- N. N. Blokhin Oncology National Medical Research Center, Ministry of Health of the Russian Federation
- Issue: Vol 53, No 7 (2019)
- Pages: 604-609
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245895
- DOI: https://doi.org/10.1007/s11094-019-02046-4
- ID: 245895
Cite item
Abstract
Use of formylindolylacetic acid as a reagent at the stage of preparing the glycosides of bis(indolyl)furan-2,5-diones and dioxane as solvent increased yields from 5 – 10% to 60 – 63%, decreased the duration of the reaction from 6 h to 2 h, and significantly simplified extraction of products adequate for use at the next stage of photochemical oxidation to furancarbazole derivatives. New data are presented on the cytotoxic activity of the indocarbazole N-glycosides synthesized here, covering a wide range of cell structures and giving a more complete view of the antiproliferative properties of the compounds synthesized.
About the authors
L. V. Éktova
N. N. Blokhin Oncology National Medical Research Center, Ministry of Health of the Russian Federation
Author for correspondence.
Email: ektova@ronc.ru
Russian Federation, 24 Kashirskoe Chaussee, Moscow, 115478
O. V. Goryunova
N. N. Blokhin Oncology National Medical Research Center, Ministry of Health of the Russian Federation
Email: ektova@ronc.ru
Russian Federation, 24 Kashirskoe Chaussee, Moscow, 115478
V. A. Eremina
N. N. Blokhin Oncology National Medical Research Center, Ministry of Health of the Russian Federation
Email: ektova@ronc.ru
Russian Federation, 24 Kashirskoe Chaussee, Moscow, 115478
N. I. Tikhonova
N. N. Blokhin Oncology National Medical Research Center, Ministry of Health of the Russian Federation
Email: ektova@ronc.ru
Russian Federation, 24 Kashirskoe Chaussee, Moscow, 115478
L. A. Medvedeva
N. N. Blokhin Oncology National Medical Research Center, Ministry of Health of the Russian Federation
Email: ektova@ronc.ru
Russian Federation, 24 Kashirskoe Chaussee, Moscow, 115478