Мақаланы E-mail арқылы жіберу Synthesis, Structural Characterization and Cancer Cell Cytotoxic Activity of Vadimezan Hydrazones
- Авторлар: Zhang S.1, Xu F.2, Ge Q.3, Li H.4, Hu W.5
-
Мекемелер:
- Science Research Department, Zhejiang Chinese Medical University
- Biopharmaceutical Research and Development Center, Taizhou Vocational & Technical College
- Hangzhou Minsheng Pharmaceutical Group Co., Ltd.
- Nantong Center for Disease Control and Prevention
- College of Pharmaceutical Science, Zhejiang University of Technology
- Шығарылым: Том 50, № 6 (2016)
- Беттер: 377-381
- Бөлім: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244399
- DOI: https://doi.org/10.1007/s11094-016-1455-5
- ID: 244399
Дәйексөз келтіру
Ашық рұқсат
Рұқсат берілді
Тек жазылушылар үшін
Аннотация
New vadimezan hydrazones were synthesized as E/Z isomers and characterized by IR, 1H NMR, MS, and HRMS techniques; the ratio of isomers was analyzed by NOESY spectra. All compounds were evaluated for their cytotoxic activities against endometrial Ishikawa, lung A549 and NCI-460, chorion Bewo, cervical HeLa and Siha, breast MCF-7, leukemia HL-60, liver BEL-7402, and stomach BGC-823 cancer cell lines in vitro by standard MTT assay. The preliminary pharmacological results indicated that compound 5c exhibited most promising cytotoxic activity against NCI-460 cell line with IC50 value of 7.01 ± 0.53 μM.
Негізгі сөздер
Авторлар туралы
Shi-Jie Zhang
Science Research Department, Zhejiang Chinese Medical University
Хат алмасуға жауапты Автор.
Email: medchem@zcmu.edu.cn
ҚХР, Hangzhou, 310053
Feng Xu
Biopharmaceutical Research and Development Center, Taizhou Vocational & Technical College
Email: medchem@zcmu.edu.cn
ҚХР, Taizhou, 31800
Qiu-Fu Ge
Hangzhou Minsheng Pharmaceutical Group Co., Ltd.
Email: medchem@zcmu.edu.cn
ҚХР, Hangzhou, 310011
Hai-Bo Li
Nantong Center for Disease Control and Prevention
Email: medchem@zcmu.edu.cn
ҚХР, Nantong, 226007
Wei-Xiao Hu
College of Pharmaceutical Science, Zhejiang University of Technology
Email: medchem@zcmu.edu.cn
ҚХР, Hangzhou, 310032
