Synthesis, Structural Characterization and Cancer Cell Cytotoxic Activity of Vadimezan Hydrazones


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Abstract

New vadimezan hydrazones were synthesized as E/Z isomers and characterized by IR, 1H NMR, MS, and HRMS techniques; the ratio of isomers was analyzed by NOESY spectra. All compounds were evaluated for their cytotoxic activities against endometrial Ishikawa, lung A549 and NCI-460, chorion Bewo, cervical HeLa and Siha, breast MCF-7, leukemia HL-60, liver BEL-7402, and stomach BGC-823 cancer cell lines in vitro by standard MTT assay. The preliminary pharmacological results indicated that compound 5c exhibited most promising cytotoxic activity against NCI-460 cell line with IC50 value of 7.01 ± 0.53 μM.

About the authors

Shi-Jie Zhang

Science Research Department, Zhejiang Chinese Medical University

Author for correspondence.
Email: medchem@zcmu.edu.cn
China, Hangzhou, 310053

Feng Xu

Biopharmaceutical Research and Development Center, Taizhou Vocational & Technical College

Email: medchem@zcmu.edu.cn
China, Taizhou, 31800

Qiu-Fu Ge

Hangzhou Minsheng Pharmaceutical Group Co., Ltd.

Email: medchem@zcmu.edu.cn
China, Hangzhou, 310011

Hai-Bo Li

Nantong Center for Disease Control and Prevention

Email: medchem@zcmu.edu.cn
China, Nantong, 226007

Wei-Xiao Hu

College of Pharmaceutical Science, Zhejiang University of Technology

Email: medchem@zcmu.edu.cn
China, Hangzhou, 310032

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