电邮这篇文章 Synthesis, Structural Characterization and Cancer Cell Cytotoxic Activity of Vadimezan Hydrazones
- 作者: Zhang S.1, Xu F.2, Ge Q.3, Li H.4, Hu W.5
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隶属关系:
- Science Research Department, Zhejiang Chinese Medical University
- Biopharmaceutical Research and Development Center, Taizhou Vocational & Technical College
- Hangzhou Minsheng Pharmaceutical Group Co., Ltd.
- Nantong Center for Disease Control and Prevention
- College of Pharmaceutical Science, Zhejiang University of Technology
- 期: 卷 50, 编号 6 (2016)
- 页面: 377-381
- 栏目: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244399
- DOI: https://doi.org/10.1007/s11094-016-1455-5
- ID: 244399
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详细
New vadimezan hydrazones were synthesized as E/Z isomers and characterized by IR, 1H NMR, MS, and HRMS techniques; the ratio of isomers was analyzed by NOESY spectra. All compounds were evaluated for their cytotoxic activities against endometrial Ishikawa, lung A549 and NCI-460, chorion Bewo, cervical HeLa and Siha, breast MCF-7, leukemia HL-60, liver BEL-7402, and stomach BGC-823 cancer cell lines in vitro by standard MTT assay. The preliminary pharmacological results indicated that compound 5c exhibited most promising cytotoxic activity against NCI-460 cell line with IC50 value of 7.01 ± 0.53 μM.
作者简介
Shi-Jie Zhang
Science Research Department, Zhejiang Chinese Medical University
编辑信件的主要联系方式.
Email: medchem@zcmu.edu.cn
中国, Hangzhou, 310053
Feng Xu
Biopharmaceutical Research and Development Center, Taizhou Vocational & Technical College
Email: medchem@zcmu.edu.cn
中国, Taizhou, 31800
Qiu-Fu Ge
Hangzhou Minsheng Pharmaceutical Group Co., Ltd.
Email: medchem@zcmu.edu.cn
中国, Hangzhou, 310011
Hai-Bo Li
Nantong Center for Disease Control and Prevention
Email: medchem@zcmu.edu.cn
中国, Nantong, 226007
Wei-Xiao Hu
College of Pharmaceutical Science, Zhejiang University of Technology
Email: medchem@zcmu.edu.cn
中国, Hangzhou, 310032
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