Email this article Synthesis, Antimicrobial Activity, and Behavioral Response Effects of N-Substituted 4-Aryl-2-Hydroxy-4-Oxobut-2-Enoic Acid Hydrazides and Their Metal Complexes
- Authors: Pulina N.A.1, Kuznetsov A.S.1, Krasnova A.I.1, Novikova V.V.1
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Affiliations:
- Perm State Pharmaceutical Academy, Ministry of Health of the Russian Federation
- Issue: Vol 53, No 3 (2019)
- Pages: 220-224
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245703
- DOI: https://doi.org/10.1007/s11094-019-01983-4
- ID: 245703
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Abstract
N-Substituted 4-aryl-2-hydroxy-4-oxobut-2-enoic acid hydrazides and their complexes with Ni(II), Mn(II), Co(II), Cu(II), and Zn(II) were prepared. Their antimicrobial activity and behavioral response effects in mice were studied. Compounds with low acute toxicities and activities comparable to or exceeding those of the reference drugs were discovered.
About the authors
N. A. Pulina
Perm State Pharmaceutical Academy, Ministry of Health of the Russian Federation
Author for correspondence.
Email: pulina-nata@mail.ru
Russian Federation, Perm, Perm Krai, 614990
A. S. Kuznetsov
Perm State Pharmaceutical Academy, Ministry of Health of the Russian Federation
Email: pulina-nata@mail.ru
Russian Federation, Perm, Perm Krai, 614990
A. I. Krasnova
Perm State Pharmaceutical Academy, Ministry of Health of the Russian Federation
Email: pulina-nata@mail.ru
Russian Federation, Perm, Perm Krai, 614990
V. V. Novikova
Perm State Pharmaceutical Academy, Ministry of Health of the Russian Federation
Email: pulina-nata@mail.ru
Russian Federation, Perm, Perm Krai, 614990
