Email this article The Main Structural Types of Inhibitors of Matrix Metalloproteinases
- Authors: Kapranov L.E.1, Reznikov A.N.1, Klimochkin Y.N.1
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Affiliations:
- Samara State Technical University
- Issue: Vol 51, No 3 (2017)
- Pages: 175-181
- Section: Search for New Drugs
- URL: https://journals.rcsi.science/0091-150X/article/view/244524
- DOI: https://doi.org/10.1007/s11094-017-1577-4
- ID: 244524
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Abstract
This review addresses the main structural types of matrix metalloproteinase (MMP) inhibitors - hydroxamic acid derivatives, sulfonamides, bisphosphonates, compounds combining phosphoryl and hydroxamate groups, and functional derivatives of phosphonic and phosphinic acids. The selectivity of the inhibitory actions of these substances in relation to different types of MMP and the potential for the practical application of these substances in cancer treatment are discussed.
About the authors
L. E. Kapranov
Samara State Technical University
Email: orgphosphorus@yandex.ru
Russian Federation, 244 Molodogvardeiskaya Street, Samara, 443100
A. N. Reznikov
Samara State Technical University
Author for correspondence.
Email: orgphosphorus@yandex.ru
Russian Federation, 244 Molodogvardeiskaya Street, Samara, 443100
Yu. N. Klimochkin
Samara State Technical University
Email: orgphosphorus@yandex.ru
Russian Federation, 244 Molodogvardeiskaya Street, Samara, 443100
