Combination of Mesenchymal Stromal Cells and Cardiac Stem Cells in a Multilayer Cell Construct Promotes Activation of Notch Signaling and Initiation of Endothelial Differentiation
- 作者: Shevchenko E.1, Dergilev K.1, Tsokolaeva Z.1, Beloglazova I.1, Molokotina Y.1, Parfenova E.1, Men’shikov M.1
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隶属关系:
- National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
- 期: 卷 166, 编号 4 (2019)
- 页面: 548-552
- 栏目: Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
- URL: https://journals.rcsi.science/0007-4888/article/view/241174
- DOI: https://doi.org/10.1007/s10517-019-04390-7
- ID: 241174
如何引用文章
详细
We showed the possibility of generating combined tissue-engineered cell consisting of layers of rat cardiac stem cells and mesenchymal stromal cells from the adipose tissue. Cell—cell interaction within the cell sheet promoted proliferation of cardiac stem cells, expression of endothelial differentiation marker ETS1, and Notch signaling activation. The obtained results provide new insights into possible mechanisms of stimulation of endogenous regeneration processes after myocardial damage and demonstrate potential of cell-based cardiomyoplasty with the use of these combined cell sheets.
作者简介
E. Shevchenko
National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
编辑信件的主要联系方式.
Email: dr.eshevchenko@gmail.com
俄罗斯联邦, Moscow
K. Dergilev
National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: dr.eshevchenko@gmail.com
俄罗斯联邦, Moscow
Z. Tsokolaeva
National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: dr.eshevchenko@gmail.com
俄罗斯联邦, Moscow
I. Beloglazova
National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: dr.eshevchenko@gmail.com
俄罗斯联邦, Moscow
Yu. Molokotina
National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: dr.eshevchenko@gmail.com
俄罗斯联邦, Moscow
E. Parfenova
National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: dr.eshevchenko@gmail.com
俄罗斯联邦, Moscow
M. Men’shikov
National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: dr.eshevchenko@gmail.com
俄罗斯联邦, Moscow