Combination of Mesenchymal Stromal Cells and Cardiac Stem Cells in a Multilayer Cell Construct Promotes Activation of Notch Signaling and Initiation of Endothelial Differentiation
- Авторлар: Shevchenko E.1, Dergilev K.1, Tsokolaeva Z.1, Beloglazova I.1, Molokotina Y.1, Parfenova E.1, Men’shikov M.1
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Мекемелер:
- National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
- Шығарылым: Том 166, № 4 (2019)
- Беттер: 548-552
- Бөлім: Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
- URL: https://journals.rcsi.science/0007-4888/article/view/241174
- DOI: https://doi.org/10.1007/s10517-019-04390-7
- ID: 241174
Дәйексөз келтіру
Аннотация
We showed the possibility of generating combined tissue-engineered cell consisting of layers of rat cardiac stem cells and mesenchymal stromal cells from the adipose tissue. Cell—cell interaction within the cell sheet promoted proliferation of cardiac stem cells, expression of endothelial differentiation marker ETS1, and Notch signaling activation. The obtained results provide new insights into possible mechanisms of stimulation of endogenous regeneration processes after myocardial damage and demonstrate potential of cell-based cardiomyoplasty with the use of these combined cell sheets.
Авторлар туралы
E. Shevchenko
National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Хат алмасуға жауапты Автор.
Email: dr.eshevchenko@gmail.com
Ресей, Moscow
K. Dergilev
National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: dr.eshevchenko@gmail.com
Ресей, Moscow
Z. Tsokolaeva
National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: dr.eshevchenko@gmail.com
Ресей, Moscow
I. Beloglazova
National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: dr.eshevchenko@gmail.com
Ресей, Moscow
Yu. Molokotina
National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: dr.eshevchenko@gmail.com
Ресей, Moscow
E. Parfenova
National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: dr.eshevchenko@gmail.com
Ресей, Moscow
M. Men’shikov
National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: dr.eshevchenko@gmail.com
Ресей, Moscow