Reinforced Hybrid Collagen Sponges for Tissue Engineering


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We created an anisotropic material based on collagen sponge and reactive polylactide structured by laser photopolymerization. The combination of collagen with reactive polylactide improves the resistance of the formed matrices to biodegradation in comparison with collagen sponge, while the existence of sites with different mechanical characteristics and cell affinity on the matrix provides directed cell growth during their culturing. It was shown that reinforcement of the collagen sponges 7-fold increased the mean Young’s modulus for the hybrid matrix without affecting its cytotoxicity. The developed matrix provides cell adhesion and proliferation along reinforcement lines and can be used for fabrication of tissue engineering constructs.

作者简介

K. Bardakova

Institute of Photonics Technologies, Federal Research Centre “Crystallography and Photonics”, Russian Academy of Sciences; Institute of Regenerative Medicine, I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation

Email: rubenchail@yandex.ru
俄罗斯联邦, Moscow; Moscow

E. Grebenik

Institute of Regenerative Medicine, I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation

Email: rubenchail@yandex.ru
俄罗斯联邦, Moscow

E. Istranova

Institute of Regenerative Medicine, I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation

Email: rubenchail@yandex.ru
俄罗斯联邦, Moscow

L. Istranov

Institute of Regenerative Medicine, I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation

Email: rubenchail@yandex.ru
俄罗斯联邦, Moscow

Yu. Gerasimov

N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation

Email: rubenchail@yandex.ru
俄罗斯联邦, Moscow

A. Grosheva

N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation

Email: rubenchail@yandex.ru
俄罗斯联邦, Moscow

T. Zharikova

Institute of Regenerative Medicine, I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation

Email: rubenchail@yandex.ru
俄罗斯联邦, Moscow

N. Minaev

Institute of Photonics Technologies, Federal Research Centre “Crystallography and Photonics”, Russian Academy of Sciences

Email: rubenchail@yandex.ru
俄罗斯联邦, Moscow

B. Shavkuta

Institute of Photonics Technologies, Federal Research Centre “Crystallography and Photonics”, Russian Academy of Sciences; Institute of Regenerative Medicine, I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation

Email: rubenchail@yandex.ru
俄罗斯联邦, Moscow; Moscow

D. Dudova

Institute of Photonics Technologies, Federal Research Centre “Crystallography and Photonics”, Russian Academy of Sciences

Email: rubenchail@yandex.ru
俄罗斯联邦, Moscow

S. Kostyuk

Research Institute for Physical Chemical Problems, Belarusian State University

Email: rubenchail@yandex.ru
白俄罗斯, Minsk

N. Vorob’eva

Institute of Photonics Technologies, Federal Research Centre “Crystallography and Photonics”, Russian Academy of Sciences

Email: rubenchail@yandex.ru
俄罗斯联邦, Moscow

V. Bagratashvili

Institute of Photonics Technologies, Federal Research Centre “Crystallography and Photonics”, Russian Academy of Sciences

Email: rubenchail@yandex.ru
俄罗斯联邦, Moscow

P. Timashev

Institute of Photonics Technologies, Federal Research Centre “Crystallography and Photonics”, Russian Academy of Sciences; Institute of Regenerative Medicine, I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation

Email: rubenchail@yandex.ru
俄罗斯联邦, Moscow; Moscow

R. Chailakhyan

Institute of Photonics Technologies, Federal Research Centre “Crystallography and Photonics”, Russian Academy of Sciences; N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation

编辑信件的主要联系方式.
Email: rubenchail@yandex.ru
俄罗斯联邦, Moscow; Moscow


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