Email this article Reinforced Hybrid Collagen Sponges for Tissue Engineering
- Authors: Bardakova K.N.1,2, Grebenik E.A.2, Istranova E.V.2, Istranov L.P.2, Gerasimov Y.V.3, Grosheva A.G.3, Zharikova T.M.2, Minaev N.V.1, Shavkuta B.S.1,2, Dudova D.S.1, Kostyuk S.V.4, Vorob’eva N.N.1, Bagratashvili V.N.1, Timashev P.S.1,2, Chailakhyan R.K.1,3
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Affiliations:
- Institute of Photonics Technologies, Federal Research Centre “Crystallography and Photonics”, Russian Academy of Sciences
- Institute of Regenerative Medicine, I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation
- N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
- Research Institute for Physical Chemical Problems, Belarusian State University
- Issue: Vol 165, No 1 (2018)
- Pages: 142-147
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240068
- DOI: https://doi.org/10.1007/s10517-018-4116-8
- ID: 240068
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Abstract
We created an anisotropic material based on collagen sponge and reactive polylactide structured by laser photopolymerization. The combination of collagen with reactive polylactide improves the resistance of the formed matrices to biodegradation in comparison with collagen sponge, while the existence of sites with different mechanical characteristics and cell affinity on the matrix provides directed cell growth during their culturing. It was shown that reinforcement of the collagen sponges 7-fold increased the mean Young’s modulus for the hybrid matrix without affecting its cytotoxicity. The developed matrix provides cell adhesion and proliferation along reinforcement lines and can be used for fabrication of tissue engineering constructs.
About the authors
K. N. Bardakova
Institute of Photonics Technologies, Federal Research Centre “Crystallography and Photonics”, Russian Academy of Sciences; Institute of Regenerative Medicine, I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation
Email: rubenchail@yandex.ru
Russian Federation, Moscow; Moscow
E. A. Grebenik
Institute of Regenerative Medicine, I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation
Email: rubenchail@yandex.ru
Russian Federation, Moscow
E. V. Istranova
Institute of Regenerative Medicine, I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation
Email: rubenchail@yandex.ru
Russian Federation, Moscow
L. P. Istranov
Institute of Regenerative Medicine, I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation
Email: rubenchail@yandex.ru
Russian Federation, Moscow
Yu. V. Gerasimov
N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Email: rubenchail@yandex.ru
Russian Federation, Moscow
A. G. Grosheva
N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Email: rubenchail@yandex.ru
Russian Federation, Moscow
T. M. Zharikova
Institute of Regenerative Medicine, I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation
Email: rubenchail@yandex.ru
Russian Federation, Moscow
N. V. Minaev
Institute of Photonics Technologies, Federal Research Centre “Crystallography and Photonics”, Russian Academy of Sciences
Email: rubenchail@yandex.ru
Russian Federation, Moscow
B. S. Shavkuta
Institute of Photonics Technologies, Federal Research Centre “Crystallography and Photonics”, Russian Academy of Sciences; Institute of Regenerative Medicine, I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation
Email: rubenchail@yandex.ru
Russian Federation, Moscow; Moscow
D. S. Dudova
Institute of Photonics Technologies, Federal Research Centre “Crystallography and Photonics”, Russian Academy of Sciences
Email: rubenchail@yandex.ru
Russian Federation, Moscow
S. V. Kostyuk
Research Institute for Physical Chemical Problems, Belarusian State University
Email: rubenchail@yandex.ru
Belarus, Minsk
N. N. Vorob’eva
Institute of Photonics Technologies, Federal Research Centre “Crystallography and Photonics”, Russian Academy of Sciences
Email: rubenchail@yandex.ru
Russian Federation, Moscow
V. N. Bagratashvili
Institute of Photonics Technologies, Federal Research Centre “Crystallography and Photonics”, Russian Academy of Sciences
Email: rubenchail@yandex.ru
Russian Federation, Moscow
P. S. Timashev
Institute of Photonics Technologies, Federal Research Centre “Crystallography and Photonics”, Russian Academy of Sciences; Institute of Regenerative Medicine, I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation
Email: rubenchail@yandex.ru
Russian Federation, Moscow; Moscow
R. K. Chailakhyan
Institute of Photonics Technologies, Federal Research Centre “Crystallography and Photonics”, Russian Academy of Sciences; N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Author for correspondence.
Email: rubenchail@yandex.ru
Russian Federation, Moscow; Moscow
