Antibacterial Effects of Liposomes Containing Phospholipid Cardiolipin and Fluoroquinolone Levofloxacin on Mycobacterium tuberculosis with Extensive Drug Resistance
- 作者: Gaidukevich S.1, Mikulovich Y.1, Smirnova T.2, Andreevskaya S.2, Sorokoumova G.1, Chernousova L.2, Selishcheva A.3, Shvets V.1
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隶属关系:
- M. V. Lomonosov Moscow State University of Fine Chemical Technologies
- Central Research Institute of Tuberculosis, Russian Academy of Medical Sciences
- M. V. Lomonosov Moscow State University
- 期: 卷 160, 编号 5 (2016)
- 页面: 675-678
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236883
- DOI: https://doi.org/10.1007/s10517-016-3247-z
- ID: 236883
如何引用文章
详细
The effects of liposomes containing phospholipid cardiolipin without antibiotic and loaded with levofloxacin on the growth of Mycobacterium tuberculosis with extensive drug resistance were studied in vitro. Liposomes consisting of cardiolipin alone in a concentration of 335 μM completely suppressed the growth of M. tuberculosis. In order to reduce the minimum inhibitory concentration of cardiolipin, complex liposome preparation consisting of phosphatidylcholin/cholesterol/cardiolipin and loaded with levofloxacin was prepared. Due to this, the cardiolipin concentration was reduced to 33.5 μM (50 μg/ml) and concentration of levofloxacin – to 2 μg/ml.
作者简介
S. Gaidukevich
M. V. Lomonosov Moscow State University of Fine Chemical Technologies
Email: galinams@yandex.ru
俄罗斯联邦, Moscow
Yu. Mikulovich
M. V. Lomonosov Moscow State University of Fine Chemical Technologies
Email: galinams@yandex.ru
俄罗斯联邦, Moscow
T. Smirnova
Central Research Institute of Tuberculosis, Russian Academy of Medical Sciences
Email: galinams@yandex.ru
俄罗斯联邦, Moscow
S. Andreevskaya
Central Research Institute of Tuberculosis, Russian Academy of Medical Sciences
Email: galinams@yandex.ru
俄罗斯联邦, Moscow
G. Sorokoumova
M. V. Lomonosov Moscow State University of Fine Chemical Technologies
编辑信件的主要联系方式.
Email: galinams@yandex.ru
俄罗斯联邦, Moscow
L. Chernousova
Central Research Institute of Tuberculosis, Russian Academy of Medical Sciences
Email: galinams@yandex.ru
俄罗斯联邦, Moscow
A. Selishcheva
M. V. Lomonosov Moscow State University
Email: galinams@yandex.ru
俄罗斯联邦, Moscow
V. Shvets
M. V. Lomonosov Moscow State University of Fine Chemical Technologies
Email: galinams@yandex.ru
俄罗斯联邦, Moscow