Antibacterial Effects of Liposomes Containing Phospholipid Cardiolipin and Fluoroquinolone Levofloxacin on Mycobacterium tuberculosis with Extensive Drug Resistance
- Авторы: Gaidukevich S.1, Mikulovich Y.1, Smirnova T.2, Andreevskaya S.2, Sorokoumova G.1, Chernousova L.2, Selishcheva A.3, Shvets V.1
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Учреждения:
- M. V. Lomonosov Moscow State University of Fine Chemical Technologies
- Central Research Institute of Tuberculosis, Russian Academy of Medical Sciences
- M. V. Lomonosov Moscow State University
- Выпуск: Том 160, № 5 (2016)
- Страницы: 675-678
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236883
- DOI: https://doi.org/10.1007/s10517-016-3247-z
- ID: 236883
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Аннотация
The effects of liposomes containing phospholipid cardiolipin without antibiotic and loaded with levofloxacin on the growth of Mycobacterium tuberculosis with extensive drug resistance were studied in vitro. Liposomes consisting of cardiolipin alone in a concentration of 335 μM completely suppressed the growth of M. tuberculosis. In order to reduce the minimum inhibitory concentration of cardiolipin, complex liposome preparation consisting of phosphatidylcholin/cholesterol/cardiolipin and loaded with levofloxacin was prepared. Due to this, the cardiolipin concentration was reduced to 33.5 μM (50 μg/ml) and concentration of levofloxacin – to 2 μg/ml.
Об авторах
S. Gaidukevich
M. V. Lomonosov Moscow State University of Fine Chemical Technologies
Email: galinams@yandex.ru
Россия, Moscow
Yu. Mikulovich
M. V. Lomonosov Moscow State University of Fine Chemical Technologies
Email: galinams@yandex.ru
Россия, Moscow
T. Smirnova
Central Research Institute of Tuberculosis, Russian Academy of Medical Sciences
Email: galinams@yandex.ru
Россия, Moscow
S. Andreevskaya
Central Research Institute of Tuberculosis, Russian Academy of Medical Sciences
Email: galinams@yandex.ru
Россия, Moscow
G. Sorokoumova
M. V. Lomonosov Moscow State University of Fine Chemical Technologies
Автор, ответственный за переписку.
Email: galinams@yandex.ru
Россия, Moscow
L. Chernousova
Central Research Institute of Tuberculosis, Russian Academy of Medical Sciences
Email: galinams@yandex.ru
Россия, Moscow
A. Selishcheva
M. V. Lomonosov Moscow State University
Email: galinams@yandex.ru
Россия, Moscow
V. Shvets
M. V. Lomonosov Moscow State University of Fine Chemical Technologies
Email: galinams@yandex.ru
Россия, Moscow