Antibacterial Effects of Liposomes Containing Phospholipid Cardiolipin and Fluoroquinolone Levofloxacin on Mycobacterium tuberculosis with Extensive Drug Resistance
- Autores: Gaidukevich S.1, Mikulovich Y.1, Smirnova T.2, Andreevskaya S.2, Sorokoumova G.1, Chernousova L.2, Selishcheva A.3, Shvets V.1
-
Afiliações:
- M. V. Lomonosov Moscow State University of Fine Chemical Technologies
- Central Research Institute of Tuberculosis, Russian Academy of Medical Sciences
- M. V. Lomonosov Moscow State University
- Edição: Volume 160, Nº 5 (2016)
- Páginas: 675-678
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236883
- DOI: https://doi.org/10.1007/s10517-016-3247-z
- ID: 236883
Citar
Resumo
The effects of liposomes containing phospholipid cardiolipin without antibiotic and loaded with levofloxacin on the growth of Mycobacterium tuberculosis with extensive drug resistance were studied in vitro. Liposomes consisting of cardiolipin alone in a concentration of 335 μM completely suppressed the growth of M. tuberculosis. In order to reduce the minimum inhibitory concentration of cardiolipin, complex liposome preparation consisting of phosphatidylcholin/cholesterol/cardiolipin and loaded with levofloxacin was prepared. Due to this, the cardiolipin concentration was reduced to 33.5 μM (50 μg/ml) and concentration of levofloxacin – to 2 μg/ml.
Sobre autores
S. Gaidukevich
M. V. Lomonosov Moscow State University of Fine Chemical Technologies
Email: galinams@yandex.ru
Rússia, Moscow
Yu. Mikulovich
M. V. Lomonosov Moscow State University of Fine Chemical Technologies
Email: galinams@yandex.ru
Rússia, Moscow
T. Smirnova
Central Research Institute of Tuberculosis, Russian Academy of Medical Sciences
Email: galinams@yandex.ru
Rússia, Moscow
S. Andreevskaya
Central Research Institute of Tuberculosis, Russian Academy of Medical Sciences
Email: galinams@yandex.ru
Rússia, Moscow
G. Sorokoumova
M. V. Lomonosov Moscow State University of Fine Chemical Technologies
Autor responsável pela correspondência
Email: galinams@yandex.ru
Rússia, Moscow
L. Chernousova
Central Research Institute of Tuberculosis, Russian Academy of Medical Sciences
Email: galinams@yandex.ru
Rússia, Moscow
A. Selishcheva
M. V. Lomonosov Moscow State University
Email: galinams@yandex.ru
Rússia, Moscow
V. Shvets
M. V. Lomonosov Moscow State University of Fine Chemical Technologies
Email: galinams@yandex.ru
Rússia, Moscow