Antibacterial Effects of Liposomes Containing Phospholipid Cardiolipin and Fluoroquinolone Levofloxacin on Mycobacterium tuberculosis with Extensive Drug Resistance
- Authors: Gaidukevich S.K.1, Mikulovich Y.L.1, Smirnova T.G.2, Andreevskaya S.N.2, Sorokoumova G.M.1, Chernousova L.N.2, Selishcheva A.A.3, Shvets V.I.1
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Affiliations:
- M. V. Lomonosov Moscow State University of Fine Chemical Technologies
- Central Research Institute of Tuberculosis, Russian Academy of Medical Sciences
- M. V. Lomonosov Moscow State University
- Issue: Vol 160, No 5 (2016)
- Pages: 675-678
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236883
- DOI: https://doi.org/10.1007/s10517-016-3247-z
- ID: 236883
Cite item
Abstract
The effects of liposomes containing phospholipid cardiolipin without antibiotic and loaded with levofloxacin on the growth of Mycobacterium tuberculosis with extensive drug resistance were studied in vitro. Liposomes consisting of cardiolipin alone in a concentration of 335 μM completely suppressed the growth of M. tuberculosis. In order to reduce the minimum inhibitory concentration of cardiolipin, complex liposome preparation consisting of phosphatidylcholin/cholesterol/cardiolipin and loaded with levofloxacin was prepared. Due to this, the cardiolipin concentration was reduced to 33.5 μM (50 μg/ml) and concentration of levofloxacin – to 2 μg/ml.
About the authors
S. K. Gaidukevich
M. V. Lomonosov Moscow State University of Fine Chemical Technologies
Email: galinams@yandex.ru
Russian Federation, Moscow
Yu. L. Mikulovich
M. V. Lomonosov Moscow State University of Fine Chemical Technologies
Email: galinams@yandex.ru
Russian Federation, Moscow
T. G. Smirnova
Central Research Institute of Tuberculosis, Russian Academy of Medical Sciences
Email: galinams@yandex.ru
Russian Federation, Moscow
S. N. Andreevskaya
Central Research Institute of Tuberculosis, Russian Academy of Medical Sciences
Email: galinams@yandex.ru
Russian Federation, Moscow
G. M. Sorokoumova
M. V. Lomonosov Moscow State University of Fine Chemical Technologies
Author for correspondence.
Email: galinams@yandex.ru
Russian Federation, Moscow
L. N. Chernousova
Central Research Institute of Tuberculosis, Russian Academy of Medical Sciences
Email: galinams@yandex.ru
Russian Federation, Moscow
A. A. Selishcheva
M. V. Lomonosov Moscow State University
Email: galinams@yandex.ru
Russian Federation, Moscow
V. I. Shvets
M. V. Lomonosov Moscow State University of Fine Chemical Technologies
Email: galinams@yandex.ru
Russian Federation, Moscow