Antibodies to Glutamate Reversed the Amnesic Effects of Proinflammatory S100A9 Protein Fibrils in Aged C57Bl/6 Mice
- Авторы: Gruden M.1, Davydova T.2, Fomina V.2, Vetrile L.2, Morozova-Roche L.3, Sewell R.4
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Учреждения:
- P. K. Anokhin Research Institute of Normal Physiology
- Research Institute of General Pathology and Pathophysiology
- Department of Medical Biochemistry and Biophysics, Umea University
- Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University
- Выпуск: Том 162, № 4 (2017)
- Страницы: 430-432
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238278
- DOI: https://doi.org/10.1007/s10517-017-3632-2
- ID: 238278
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Аннотация
Chronic intranasal administration of fibrillar structures of proinflammatory S100A9 protein impaired passive avoidance learning in old C57Bl/6 mice. Combined treatment with S100A9 fibrils and antibodies to glutamate was followed by an increase in horizontal locomotor activity of animals in the open-field test and did not disturb spatial memory.
Об авторах
M. Gruden
P. K. Anokhin Research Institute of Normal Physiology
Автор, ответственный за переписку.
Email: mgruden@mail.ru
Россия, Moscow
T. Davydova
Research Institute of General Pathology and Pathophysiology
Email: mgruden@mail.ru
Россия, Moscow
V. Fomina
Research Institute of General Pathology and Pathophysiology
Email: mgruden@mail.ru
Россия, Moscow
L. Vetrile
Research Institute of General Pathology and Pathophysiology
Email: mgruden@mail.ru
Россия, Moscow
L. Morozova-Roche
Department of Medical Biochemistry and Biophysics, Umea University
Email: mgruden@mail.ru
Швеция, Umea
R. Sewell
Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University
Email: mgruden@mail.ru
Великобритания, Cardiff, CF10, 3NB