Enviar artigo por via de e-mail Antibodies to Glutamate Reversed the Amnesic Effects of Proinflammatory S100A9 Protein Fibrils in Aged C57Bl/6 Mice
- Autores: Gruden M.1, Davydova T.2, Fomina V.2, Vetrile L.2, Morozova-Roche L.3, Sewell R.4
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Afiliações:
- P. K. Anokhin Research Institute of Normal Physiology
- Research Institute of General Pathology and Pathophysiology
- Department of Medical Biochemistry and Biophysics, Umea University
- Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University
- Edição: Volume 162, Nº 4 (2017)
- Páginas: 430-432
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238278
- DOI: https://doi.org/10.1007/s10517-017-3632-2
- ID: 238278
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Resumo
Chronic intranasal administration of fibrillar structures of proinflammatory S100A9 protein impaired passive avoidance learning in old C57Bl/6 mice. Combined treatment with S100A9 fibrils and antibodies to glutamate was followed by an increase in horizontal locomotor activity of animals in the open-field test and did not disturb spatial memory.
Sobre autores
M. Gruden
P. K. Anokhin Research Institute of Normal Physiology
Autor responsável pela correspondência
Email: mgruden@mail.ru
Rússia, Moscow
T. Davydova
Research Institute of General Pathology and Pathophysiology
Email: mgruden@mail.ru
Rússia, Moscow
V. Fomina
Research Institute of General Pathology and Pathophysiology
Email: mgruden@mail.ru
Rússia, Moscow
L. Vetrile
Research Institute of General Pathology and Pathophysiology
Email: mgruden@mail.ru
Rússia, Moscow
L. Morozova-Roche
Department of Medical Biochemistry and Biophysics, Umea University
Email: mgruden@mail.ru
Suécia, Umea
R. Sewell
Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University
Email: mgruden@mail.ru
Reino Unido da Grã-Bretanha e Irlanda do Norte, Cardiff, CF10, 3NB
