Antibodies to Glutamate Reversed the Amnesic Effects of Proinflammatory S100A9 Protein Fibrils in Aged C57Bl/6 Mice

M. A. Gruden; T. V. Davydova; V. G. Fomina; L. A. Vetrile; L. A. Morozova-Roche; R. D. E. Sewell

doi:10.1007/s10517-017-3632-2

Antibodies to Glutamate Reversed the Amnesic Effects of Proinflammatory S100A9 Protein Fibrils in Aged C57Bl/6 Mice

Авторлар: Gruden M.¹, Davydova T.², Fomina V.², Vetrile L.², Morozova-Roche L.³, Sewell R.⁴
Мекемелер:
1. P. K. Anokhin Research Institute of Normal Physiology
2. Research Institute of General Pathology and Pathophysiology
3. Department of Medical Biochemistry and Biophysics, Umea University
4. Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University
Шығарылым: Том 162, № 4 (2017)
Беттер: 430-432
Бөлім: Article
URL: https://journals.rcsi.science/0007-4888/article/view/238278
DOI: https://doi.org/10.1007/s10517-017-3632-2
ID: 238278

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Аннотация

Chronic intranasal administration of fibrillar structures of proinflammatory S100A9 protein impaired passive avoidance learning in old C57Bl/6 mice. Combined treatment with S100A9 fibrils and antibodies to glutamate was followed by an increase in horizontal locomotor activity of animals in the open-field test and did not disturb spatial memory.