Antibodies to Glutamate Reversed the Amnesic Effects of Proinflammatory S100A9 Protein Fibrils in Aged C57Bl/6 Mice
- Authors: Gruden M.A.1, Davydova T.V.2, Fomina V.G.2, Vetrile L.A.2, Morozova-Roche L.A.3, Sewell R.D.4
-
Affiliations:
- P. K. Anokhin Research Institute of Normal Physiology
- Research Institute of General Pathology and Pathophysiology
- Department of Medical Biochemistry and Biophysics, Umea University
- Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University
- Issue: Vol 162, No 4 (2017)
- Pages: 430-432
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238278
- DOI: https://doi.org/10.1007/s10517-017-3632-2
- ID: 238278
Cite item
Abstract
Chronic intranasal administration of fibrillar structures of proinflammatory S100A9 protein impaired passive avoidance learning in old C57Bl/6 mice. Combined treatment with S100A9 fibrils and antibodies to glutamate was followed by an increase in horizontal locomotor activity of animals in the open-field test and did not disturb spatial memory.
About the authors
M. A. Gruden
P. K. Anokhin Research Institute of Normal Physiology
Author for correspondence.
Email: mgruden@mail.ru
Russian Federation, Moscow
T. V. Davydova
Research Institute of General Pathology and Pathophysiology
Email: mgruden@mail.ru
Russian Federation, Moscow
V. G. Fomina
Research Institute of General Pathology and Pathophysiology
Email: mgruden@mail.ru
Russian Federation, Moscow
L. A. Vetrile
Research Institute of General Pathology and Pathophysiology
Email: mgruden@mail.ru
Russian Federation, Moscow
L. A. Morozova-Roche
Department of Medical Biochemistry and Biophysics, Umea University
Email: mgruden@mail.ru
Sweden, Umea
R. D. E. Sewell
Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University
Email: mgruden@mail.ru
United Kingdom, Cardiff, CF10, 3NB