Antibodies to Glutamate Reversed the Amnesic Effects of Proinflammatory S100A9 Protein Fibrils in Aged C57Bl/6 Mice

M. A. Gruden; T. V. Davydova; V. G. Fomina; L. A. Vetrile; L. A. Morozova-Roche; R. D. E. Sewell

doi:10.1007/s10517-017-3632-2

Antibodies to Glutamate Reversed the Amnesic Effects of Proinflammatory S100A9 Protein Fibrils in Aged C57Bl/6 Mice

Authors: Gruden M.A.¹, Davydova T.V.², Fomina V.G.², Vetrile L.A.², Morozova-Roche L.A.³, Sewell R.D.⁴
Affiliations:
1. P. K. Anokhin Research Institute of Normal Physiology
2. Research Institute of General Pathology and Pathophysiology
3. Department of Medical Biochemistry and Biophysics, Umea University
4. Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University
Issue: Vol 162, No 4 (2017)
Pages: 430-432
Section: Article
URL: https://journals.rcsi.science/0007-4888/article/view/238278
DOI: https://doi.org/10.1007/s10517-017-3632-2
ID: 238278

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Abstract

Chronic intranasal administration of fibrillar structures of proinflammatory S100A9 protein impaired passive avoidance learning in old C57Bl/6 mice. Combined treatment with S100A9 fibrils and antibodies to glutamate was followed by an increase in horizontal locomotor activity of animals in the open-field test and did not disturb spatial memory.