Antibacterial Effects of Liposomes Containing Phospholipid Cardiolipin and Fluoroquinolone Levofloxacin on Mycobacterium tuberculosis with Extensive Drug Resistance
- Авторлар: Gaidukevich S.1, Mikulovich Y.1, Smirnova T.2, Andreevskaya S.2, Sorokoumova G.1, Chernousova L.2, Selishcheva A.3, Shvets V.1
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Мекемелер:
- M. V. Lomonosov Moscow State University of Fine Chemical Technologies
- Central Research Institute of Tuberculosis, Russian Academy of Medical Sciences
- M. V. Lomonosov Moscow State University
- Шығарылым: Том 160, № 5 (2016)
- Беттер: 675-678
- Бөлім: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236883
- DOI: https://doi.org/10.1007/s10517-016-3247-z
- ID: 236883
Дәйексөз келтіру
Аннотация
The effects of liposomes containing phospholipid cardiolipin without antibiotic and loaded with levofloxacin on the growth of Mycobacterium tuberculosis with extensive drug resistance were studied in vitro. Liposomes consisting of cardiolipin alone in a concentration of 335 μM completely suppressed the growth of M. tuberculosis. In order to reduce the minimum inhibitory concentration of cardiolipin, complex liposome preparation consisting of phosphatidylcholin/cholesterol/cardiolipin and loaded with levofloxacin was prepared. Due to this, the cardiolipin concentration was reduced to 33.5 μM (50 μg/ml) and concentration of levofloxacin – to 2 μg/ml.
Авторлар туралы
S. Gaidukevich
M. V. Lomonosov Moscow State University of Fine Chemical Technologies
Email: galinams@yandex.ru
Ресей, Moscow
Yu. Mikulovich
M. V. Lomonosov Moscow State University of Fine Chemical Technologies
Email: galinams@yandex.ru
Ресей, Moscow
T. Smirnova
Central Research Institute of Tuberculosis, Russian Academy of Medical Sciences
Email: galinams@yandex.ru
Ресей, Moscow
S. Andreevskaya
Central Research Institute of Tuberculosis, Russian Academy of Medical Sciences
Email: galinams@yandex.ru
Ресей, Moscow
G. Sorokoumova
M. V. Lomonosov Moscow State University of Fine Chemical Technologies
Хат алмасуға жауапты Автор.
Email: galinams@yandex.ru
Ресей, Moscow
L. Chernousova
Central Research Institute of Tuberculosis, Russian Academy of Medical Sciences
Email: galinams@yandex.ru
Ресей, Moscow
A. Selishcheva
M. V. Lomonosov Moscow State University
Email: galinams@yandex.ru
Ресей, Moscow
V. Shvets
M. V. Lomonosov Moscow State University of Fine Chemical Technologies
Email: galinams@yandex.ru
Ресей, Moscow