Email this article Cytokine Profile in Experimental Models of Critical Limb Ischemia in Rats
- Authors: Lykov A.P.1,2, Bondarenko N.A.1,2, Poveshchenko O.V.1,2, Kabakov A.V.1, Surovtseva M.A.1,2, Kim I.I.1,2, Kazakov O.V.1, Poveshchenko A.F.1,2, Yankaite E.V.1
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Affiliations:
- Research Institute of Clinical and Experimental Lymphology, Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- E. N. Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation
- Issue: Vol 168, No 1 (2019)
- Pages: 150-155
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/242307
- DOI: https://doi.org/10.1007/s10517-019-04666-y
- ID: 242307
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Abstract
We studied the effect of intramuscular administration of a cellular product (mesenchymal stem cells, conditioned media, and erythropoietin) on cytokine levels in blood serum, conditioned media of bone marrow mononuclears, and calf muscles in Wistar rats with hind limb ischemia. It is shown that the cellular product reduces the proinflammatory background at the early stages of the experiment and increases the content proangiogenic factors.
About the authors
A. P. Lykov
Research Institute of Clinical and Experimental Lymphology, Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences; E. N. Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation
Author for correspondence.
Email: aplykov2@mail.ru
Russian Federation, Novosibirsk; Novosibirsk
N. A. Bondarenko
Research Institute of Clinical and Experimental Lymphology, Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences; E. N. Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation
Email: aplykov2@mail.ru
Russian Federation, Novosibirsk; Novosibirsk
O. V. Poveshchenko
Research Institute of Clinical and Experimental Lymphology, Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences; E. N. Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation
Email: aplykov2@mail.ru
Russian Federation, Novosibirsk; Novosibirsk
A. V. Kabakov
Research Institute of Clinical and Experimental Lymphology, Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: aplykov2@mail.ru
Russian Federation, Novosibirsk
M. A. Surovtseva
Research Institute of Clinical and Experimental Lymphology, Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences; E. N. Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation
Email: aplykov2@mail.ru
Russian Federation, Novosibirsk; Novosibirsk
I. I. Kim
Research Institute of Clinical and Experimental Lymphology, Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences; E. N. Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation
Email: aplykov2@mail.ru
Russian Federation, Novosibirsk; Novosibirsk
O. V. Kazakov
Research Institute of Clinical and Experimental Lymphology, Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: aplykov2@mail.ru
Russian Federation, Novosibirsk
A. F. Poveshchenko
Research Institute of Clinical and Experimental Lymphology, Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences; E. N. Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation
Email: aplykov2@mail.ru
Russian Federation, Novosibirsk; Novosibirsk
E. V. Yankaite
Research Institute of Clinical and Experimental Lymphology, Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: aplykov2@mail.ru
Russian Federation, Novosibirsk
