Cytokine Profile in Experimental Models of Critical Limb Ischemia in Rats


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Аннотация

We studied the effect of intramuscular administration of a cellular product (mesenchymal stem cells, conditioned media, and erythropoietin) on cytokine levels in blood serum, conditioned media of bone marrow mononuclears, and calf muscles in Wistar rats with hind limb ischemia. It is shown that the cellular product reduces the proinflammatory background at the early stages of the experiment and increases the content proangiogenic factors.

Об авторах

A. Lykov

Research Institute of Clinical and Experimental Lymphology, Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences; E. N. Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation

Автор, ответственный за переписку.
Email: aplykov2@mail.ru
Россия, Novosibirsk; Novosibirsk

N. Bondarenko

Research Institute of Clinical and Experimental Lymphology, Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences; E. N. Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation

Email: aplykov2@mail.ru
Россия, Novosibirsk; Novosibirsk

O. Poveshchenko

Research Institute of Clinical and Experimental Lymphology, Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences; E. N. Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation

Email: aplykov2@mail.ru
Россия, Novosibirsk; Novosibirsk

A. Kabakov

Research Institute of Clinical and Experimental Lymphology, Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences

Email: aplykov2@mail.ru
Россия, Novosibirsk

M. Surovtseva

Research Institute of Clinical and Experimental Lymphology, Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences; E. N. Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation

Email: aplykov2@mail.ru
Россия, Novosibirsk; Novosibirsk

I. Kim

Research Institute of Clinical and Experimental Lymphology, Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences; E. N. Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation

Email: aplykov2@mail.ru
Россия, Novosibirsk; Novosibirsk

O. Kazakov

Research Institute of Clinical and Experimental Lymphology, Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences

Email: aplykov2@mail.ru
Россия, Novosibirsk

A. Poveshchenko

Research Institute of Clinical and Experimental Lymphology, Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences; E. N. Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation

Email: aplykov2@mail.ru
Россия, Novosibirsk; Novosibirsk

E. Yankaite

Research Institute of Clinical and Experimental Lymphology, Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences

Email: aplykov2@mail.ru
Россия, Novosibirsk


© Springer Science+Business Media, LLC, part of Springer Nature, 2019

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