Cytokine Profile in Experimental Models of Critical Limb Ischemia in Rats


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We studied the effect of intramuscular administration of a cellular product (mesenchymal stem cells, conditioned media, and erythropoietin) on cytokine levels in blood serum, conditioned media of bone marrow mononuclears, and calf muscles in Wistar rats with hind limb ischemia. It is shown that the cellular product reduces the proinflammatory background at the early stages of the experiment and increases the content proangiogenic factors.

作者简介

A. Lykov

Research Institute of Clinical and Experimental Lymphology, Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences; E. N. Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation

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Email: aplykov2@mail.ru
俄罗斯联邦, Novosibirsk; Novosibirsk

N. Bondarenko

Research Institute of Clinical and Experimental Lymphology, Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences; E. N. Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation

Email: aplykov2@mail.ru
俄罗斯联邦, Novosibirsk; Novosibirsk

O. Poveshchenko

Research Institute of Clinical and Experimental Lymphology, Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences; E. N. Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation

Email: aplykov2@mail.ru
俄罗斯联邦, Novosibirsk; Novosibirsk

A. Kabakov

Research Institute of Clinical and Experimental Lymphology, Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences

Email: aplykov2@mail.ru
俄罗斯联邦, Novosibirsk

M. Surovtseva

Research Institute of Clinical and Experimental Lymphology, Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences; E. N. Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation

Email: aplykov2@mail.ru
俄罗斯联邦, Novosibirsk; Novosibirsk

I. Kim

Research Institute of Clinical and Experimental Lymphology, Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences; E. N. Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation

Email: aplykov2@mail.ru
俄罗斯联邦, Novosibirsk; Novosibirsk

O. Kazakov

Research Institute of Clinical and Experimental Lymphology, Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences

Email: aplykov2@mail.ru
俄罗斯联邦, Novosibirsk

A. Poveshchenko

Research Institute of Clinical and Experimental Lymphology, Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences; E. N. Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation

Email: aplykov2@mail.ru
俄罗斯联邦, Novosibirsk; Novosibirsk

E. Yankaite

Research Institute of Clinical and Experimental Lymphology, Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences

Email: aplykov2@mail.ru
俄罗斯联邦, Novosibirsk


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