Email this article Neuroprotective Effects of Methylene Blue In Vivo and In Vitro
- Authors: Stelmashook E.V.1, Genrikhs E.E.1, Mukhaleva E.V.1,2, Kapkaeva M.R.1, Kondratenko R.V.1, Skrebitsky V.G.1, Isaev N.K.1,2
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Affiliations:
- Research Center of Neurology
- M. V. Lomonosov Moscow State University
- Issue: Vol 167, No 4 (2019)
- Pages: 455-459
- Section: Pharmacology and Toxicology
- URL: https://journals.rcsi.science/0007-4888/article/view/241794
- DOI: https://doi.org/10.1007/s10517-019-04548-3
- ID: 241794
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Abstract
Focal unilateral traumatic brain injury in the sensorimotor cortical region disturbed the functions of contralateral limbs controlled by the damaged hemisphere. A single intravenous injection of methylene blue (1 mg/kg) immediately before or 30 min after the injury significantly weakened functional disorders in the affected extremities. In vitro experiments showed that methylene blue effectively reduced death of cultured neurons provoked by paraquat or zinc ions producing the toxic effects on mitochondrias.
About the authors
E. V. Stelmashook
Research Center of Neurology
Email: isaev@genebee.msu.ru
Russian Federation, Moscow
E. E. Genrikhs
Research Center of Neurology
Email: isaev@genebee.msu.ru
Russian Federation, Moscow
E. V. Mukhaleva
Research Center of Neurology; M. V. Lomonosov Moscow State University
Email: isaev@genebee.msu.ru
Russian Federation, Moscow; Moscow
M. R. Kapkaeva
Research Center of Neurology
Email: isaev@genebee.msu.ru
Russian Federation, Moscow
R. V. Kondratenko
Research Center of Neurology
Email: isaev@genebee.msu.ru
Russian Federation, Moscow
V. G. Skrebitsky
Research Center of Neurology
Email: isaev@genebee.msu.ru
Russian Federation, Moscow
N. K. Isaev
Research Center of Neurology; M. V. Lomonosov Moscow State University
Author for correspondence.
Email: isaev@genebee.msu.ru
Russian Federation, Moscow; Moscow
