Neuroprotective Effects of Methylene Blue In Vivo and In Vitro
- 作者: Stelmashook E.1, Genrikhs E.1, Mukhaleva E.1,2, Kapkaeva M.1, Kondratenko R.1, Skrebitsky V.1, Isaev N.1,2
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隶属关系:
- Research Center of Neurology
- M. V. Lomonosov Moscow State University
- 期: 卷 167, 编号 4 (2019)
- 页面: 455-459
- 栏目: Pharmacology and Toxicology
- URL: https://journals.rcsi.science/0007-4888/article/view/241794
- DOI: https://doi.org/10.1007/s10517-019-04548-3
- ID: 241794
如何引用文章
详细
Focal unilateral traumatic brain injury in the sensorimotor cortical region disturbed the functions of contralateral limbs controlled by the damaged hemisphere. A single intravenous injection of methylene blue (1 mg/kg) immediately before or 30 min after the injury significantly weakened functional disorders in the affected extremities. In vitro experiments showed that methylene blue effectively reduced death of cultured neurons provoked by paraquat or zinc ions producing the toxic effects on mitochondrias.
作者简介
E. Stelmashook
Research Center of Neurology
Email: isaev@genebee.msu.ru
俄罗斯联邦, Moscow
E. Genrikhs
Research Center of Neurology
Email: isaev@genebee.msu.ru
俄罗斯联邦, Moscow
E. Mukhaleva
Research Center of Neurology; M. V. Lomonosov Moscow State University
Email: isaev@genebee.msu.ru
俄罗斯联邦, Moscow; Moscow
M. Kapkaeva
Research Center of Neurology
Email: isaev@genebee.msu.ru
俄罗斯联邦, Moscow
R. Kondratenko
Research Center of Neurology
Email: isaev@genebee.msu.ru
俄罗斯联邦, Moscow
V. Skrebitsky
Research Center of Neurology
Email: isaev@genebee.msu.ru
俄罗斯联邦, Moscow
N. Isaev
Research Center of Neurology; M. V. Lomonosov Moscow State University
编辑信件的主要联系方式.
Email: isaev@genebee.msu.ru
俄罗斯联邦, Moscow; Moscow
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