Neuroprotective Effects of Methylene Blue In Vivo and In Vitro
- Авторы: Stelmashook E.1, Genrikhs E.1, Mukhaleva E.1,2, Kapkaeva M.1, Kondratenko R.1, Skrebitsky V.1, Isaev N.1,2
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Учреждения:
- Research Center of Neurology
- M. V. Lomonosov Moscow State University
- Выпуск: Том 167, № 4 (2019)
- Страницы: 455-459
- Раздел: Pharmacology and Toxicology
- URL: https://journals.rcsi.science/0007-4888/article/view/241794
- DOI: https://doi.org/10.1007/s10517-019-04548-3
- ID: 241794
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Аннотация
Focal unilateral traumatic brain injury in the sensorimotor cortical region disturbed the functions of contralateral limbs controlled by the damaged hemisphere. A single intravenous injection of methylene blue (1 mg/kg) immediately before or 30 min after the injury significantly weakened functional disorders in the affected extremities. In vitro experiments showed that methylene blue effectively reduced death of cultured neurons provoked by paraquat or zinc ions producing the toxic effects on mitochondrias.
Об авторах
E. Stelmashook
Research Center of Neurology
Email: isaev@genebee.msu.ru
Россия, Moscow
E. Genrikhs
Research Center of Neurology
Email: isaev@genebee.msu.ru
Россия, Moscow
E. Mukhaleva
Research Center of Neurology; M. V. Lomonosov Moscow State University
Email: isaev@genebee.msu.ru
Россия, Moscow; Moscow
M. Kapkaeva
Research Center of Neurology
Email: isaev@genebee.msu.ru
Россия, Moscow
R. Kondratenko
Research Center of Neurology
Email: isaev@genebee.msu.ru
Россия, Moscow
V. Skrebitsky
Research Center of Neurology
Email: isaev@genebee.msu.ru
Россия, Moscow
N. Isaev
Research Center of Neurology; M. V. Lomonosov Moscow State University
Автор, ответственный за переписку.
Email: isaev@genebee.msu.ru
Россия, Moscow; Moscow