Neuroprotective Effects of Methylene Blue In Vivo and In Vitro
- Autores: Stelmashook E.1, Genrikhs E.1, Mukhaleva E.1,2, Kapkaeva M.1, Kondratenko R.1, Skrebitsky V.1, Isaev N.1,2
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Afiliações:
- Research Center of Neurology
- M. V. Lomonosov Moscow State University
- Edição: Volume 167, Nº 4 (2019)
- Páginas: 455-459
- Seção: Pharmacology and Toxicology
- URL: https://journals.rcsi.science/0007-4888/article/view/241794
- DOI: https://doi.org/10.1007/s10517-019-04548-3
- ID: 241794
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Resumo
Focal unilateral traumatic brain injury in the sensorimotor cortical region disturbed the functions of contralateral limbs controlled by the damaged hemisphere. A single intravenous injection of methylene blue (1 mg/kg) immediately before or 30 min after the injury significantly weakened functional disorders in the affected extremities. In vitro experiments showed that methylene blue effectively reduced death of cultured neurons provoked by paraquat or zinc ions producing the toxic effects on mitochondrias.
Sobre autores
E. Stelmashook
Research Center of Neurology
Email: isaev@genebee.msu.ru
Rússia, Moscow
E. Genrikhs
Research Center of Neurology
Email: isaev@genebee.msu.ru
Rússia, Moscow
E. Mukhaleva
Research Center of Neurology; M. V. Lomonosov Moscow State University
Email: isaev@genebee.msu.ru
Rússia, Moscow; Moscow
M. Kapkaeva
Research Center of Neurology
Email: isaev@genebee.msu.ru
Rússia, Moscow
R. Kondratenko
Research Center of Neurology
Email: isaev@genebee.msu.ru
Rússia, Moscow
V. Skrebitsky
Research Center of Neurology
Email: isaev@genebee.msu.ru
Rússia, Moscow
N. Isaev
Research Center of Neurology; M. V. Lomonosov Moscow State University
Autor responsável pela correspondência
Email: isaev@genebee.msu.ru
Rússia, Moscow; Moscow