Neuroprotective Effects of Methylene Blue In Vivo and In Vitro
- Авторлар: Stelmashook E.1, Genrikhs E.1, Mukhaleva E.1,2, Kapkaeva M.1, Kondratenko R.1, Skrebitsky V.1, Isaev N.1,2
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Мекемелер:
- Research Center of Neurology
- M. V. Lomonosov Moscow State University
- Шығарылым: Том 167, № 4 (2019)
- Беттер: 455-459
- Бөлім: Pharmacology and Toxicology
- URL: https://journals.rcsi.science/0007-4888/article/view/241794
- DOI: https://doi.org/10.1007/s10517-019-04548-3
- ID: 241794
Дәйексөз келтіру
Аннотация
Focal unilateral traumatic brain injury in the sensorimotor cortical region disturbed the functions of contralateral limbs controlled by the damaged hemisphere. A single intravenous injection of methylene blue (1 mg/kg) immediately before or 30 min after the injury significantly weakened functional disorders in the affected extremities. In vitro experiments showed that methylene blue effectively reduced death of cultured neurons provoked by paraquat or zinc ions producing the toxic effects on mitochondrias.
Авторлар туралы
E. Stelmashook
Research Center of Neurology
Email: isaev@genebee.msu.ru
Ресей, Moscow
E. Genrikhs
Research Center of Neurology
Email: isaev@genebee.msu.ru
Ресей, Moscow
E. Mukhaleva
Research Center of Neurology; M. V. Lomonosov Moscow State University
Email: isaev@genebee.msu.ru
Ресей, Moscow; Moscow
M. Kapkaeva
Research Center of Neurology
Email: isaev@genebee.msu.ru
Ресей, Moscow
R. Kondratenko
Research Center of Neurology
Email: isaev@genebee.msu.ru
Ресей, Moscow
V. Skrebitsky
Research Center of Neurology
Email: isaev@genebee.msu.ru
Ресей, Moscow
N. Isaev
Research Center of Neurology; M. V. Lomonosov Moscow State University
Хат алмасуға жауапты Автор.
Email: isaev@genebee.msu.ru
Ресей, Moscow; Moscow