Email this article Glycolysis Inhibitors Monoiodoacetate and 2-Deoxyglucose as Antitumor Agents: Experimental Study on Lewis Lung Carcinoma Model
- Authors: Korshunov D.A.1, Klimov I.A.2, Ivanov V.V.2, Kondakova I.V.1
-
Affiliations:
- Research Institute of Oncology, Tomsk Natinoal Research Medical Center, Russian Academy of Sciences, Ministry of Health of Russia
- Laboratory of Biological Models, Siberian State Medical University, Ministry of Health of Russia
- Issue: Vol 165, No 5 (2018)
- Pages: 695-697
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240685
- DOI: https://doi.org/10.1007/s10517-018-4244-1
- ID: 240685
Cite item
Open Access
Access granted
Subscription Access
Abstract
Antitumor effects of glycolysis inhibitors monoiodoacetate and 2-deoxyglucose were studied on Lewis lung carcinoma model. Monoiodoacetate exhibited antitumor and antimetastatic activities, being not inferior of methotrexate (reference drug); however, the preparation also demonstrated high systemic toxicity. 2-Deoxyglucose exhibited only antitumor effect, while its antimetastatic activity did not differ from the result in the group without treatment.
About the authors
D. A. Korshunov
Research Institute of Oncology, Tomsk Natinoal Research Medical Center, Russian Academy of Sciences, Ministry of Health of Russia
Author for correspondence.
Email: ieved@ya.ru
Russian Federation, Tomsk
I. A. Klimov
Laboratory of Biological Models, Siberian State Medical University, Ministry of Health of Russia
Email: ieved@ya.ru
Russian Federation, Tomsk
V. V. Ivanov
Laboratory of Biological Models, Siberian State Medical University, Ministry of Health of Russia
Email: ieved@ya.ru
Russian Federation, Tomsk
I. V. Kondakova
Research Institute of Oncology, Tomsk Natinoal Research Medical Center, Russian Academy of Sciences, Ministry of Health of Russia
Email: ieved@ya.ru
Russian Federation, Tomsk
