Enviar artigo por via de e-mail Glycolysis Inhibitors Monoiodoacetate and 2-Deoxyglucose as Antitumor Agents: Experimental Study on Lewis Lung Carcinoma Model
- Autores: Korshunov D.1, Klimov I.2, Ivanov V.2, Kondakova I.1
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Afiliações:
- Research Institute of Oncology, Tomsk Natinoal Research Medical Center, Russian Academy of Sciences, Ministry of Health of Russia
- Laboratory of Biological Models, Siberian State Medical University, Ministry of Health of Russia
- Edição: Volume 165, Nº 5 (2018)
- Páginas: 695-697
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240685
- DOI: https://doi.org/10.1007/s10517-018-4244-1
- ID: 240685
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Resumo
Antitumor effects of glycolysis inhibitors monoiodoacetate and 2-deoxyglucose were studied on Lewis lung carcinoma model. Monoiodoacetate exhibited antitumor and antimetastatic activities, being not inferior of methotrexate (reference drug); however, the preparation also demonstrated high systemic toxicity. 2-Deoxyglucose exhibited only antitumor effect, while its antimetastatic activity did not differ from the result in the group without treatment.
Sobre autores
D. Korshunov
Research Institute of Oncology, Tomsk Natinoal Research Medical Center, Russian Academy of Sciences, Ministry of Health of Russia
Autor responsável pela correspondência
Email: ieved@ya.ru
Rússia, Tomsk
I. Klimov
Laboratory of Biological Models, Siberian State Medical University, Ministry of Health of Russia
Email: ieved@ya.ru
Rússia, Tomsk
V. Ivanov
Laboratory of Biological Models, Siberian State Medical University, Ministry of Health of Russia
Email: ieved@ya.ru
Rússia, Tomsk
I. Kondakova
Research Institute of Oncology, Tomsk Natinoal Research Medical Center, Russian Academy of Sciences, Ministry of Health of Russia
Email: ieved@ya.ru
Rússia, Tomsk
