Glycolysis Inhibitors Monoiodoacetate and 2-Deoxyglucose as Antitumor Agents: Experimental Study on Lewis Lung Carcinoma Model
- 作者: Korshunov D.1, Klimov I.2, Ivanov V.2, Kondakova I.1
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隶属关系:
- Research Institute of Oncology, Tomsk Natinoal Research Medical Center, Russian Academy of Sciences, Ministry of Health of Russia
- Laboratory of Biological Models, Siberian State Medical University, Ministry of Health of Russia
- 期: 卷 165, 编号 5 (2018)
- 页面: 695-697
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240685
- DOI: https://doi.org/10.1007/s10517-018-4244-1
- ID: 240685
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详细
Antitumor effects of glycolysis inhibitors monoiodoacetate and 2-deoxyglucose were studied on Lewis lung carcinoma model. Monoiodoacetate exhibited antitumor and antimetastatic activities, being not inferior of methotrexate (reference drug); however, the preparation also demonstrated high systemic toxicity. 2-Deoxyglucose exhibited only antitumor effect, while its antimetastatic activity did not differ from the result in the group without treatment.
作者简介
D. Korshunov
Research Institute of Oncology, Tomsk Natinoal Research Medical Center, Russian Academy of Sciences, Ministry of Health of Russia
编辑信件的主要联系方式.
Email: ieved@ya.ru
俄罗斯联邦, Tomsk
I. Klimov
Laboratory of Biological Models, Siberian State Medical University, Ministry of Health of Russia
Email: ieved@ya.ru
俄罗斯联邦, Tomsk
V. Ivanov
Laboratory of Biological Models, Siberian State Medical University, Ministry of Health of Russia
Email: ieved@ya.ru
俄罗斯联邦, Tomsk
I. Kondakova
Research Institute of Oncology, Tomsk Natinoal Research Medical Center, Russian Academy of Sciences, Ministry of Health of Russia
Email: ieved@ya.ru
俄罗斯联邦, Tomsk
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