Отправить статью по E-mail Glycolysis Inhibitors Monoiodoacetate and 2-Deoxyglucose as Antitumor Agents: Experimental Study on Lewis Lung Carcinoma Model
- Авторы: Korshunov D.1, Klimov I.2, Ivanov V.2, Kondakova I.1
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Учреждения:
- Research Institute of Oncology, Tomsk Natinoal Research Medical Center, Russian Academy of Sciences, Ministry of Health of Russia
- Laboratory of Biological Models, Siberian State Medical University, Ministry of Health of Russia
- Выпуск: Том 165, № 5 (2018)
- Страницы: 695-697
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240685
- DOI: https://doi.org/10.1007/s10517-018-4244-1
- ID: 240685
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Аннотация
Antitumor effects of glycolysis inhibitors monoiodoacetate and 2-deoxyglucose were studied on Lewis lung carcinoma model. Monoiodoacetate exhibited antitumor and antimetastatic activities, being not inferior of methotrexate (reference drug); however, the preparation also demonstrated high systemic toxicity. 2-Deoxyglucose exhibited only antitumor effect, while its antimetastatic activity did not differ from the result in the group without treatment.
Об авторах
D. Korshunov
Research Institute of Oncology, Tomsk Natinoal Research Medical Center, Russian Academy of Sciences, Ministry of Health of Russia
Автор, ответственный за переписку.
Email: ieved@ya.ru
Россия, Tomsk
I. Klimov
Laboratory of Biological Models, Siberian State Medical University, Ministry of Health of Russia
Email: ieved@ya.ru
Россия, Tomsk
V. Ivanov
Laboratory of Biological Models, Siberian State Medical University, Ministry of Health of Russia
Email: ieved@ya.ru
Россия, Tomsk
I. Kondakova
Research Institute of Oncology, Tomsk Natinoal Research Medical Center, Russian Academy of Sciences, Ministry of Health of Russia
Email: ieved@ya.ru
Россия, Tomsk
