Email this article Effect of Intramuscular Administration of Mesenchymal Stem Cells and Erythropoietin on Angiogenesis in Critical Limb Ischemia
- Authors: Lykov A.P.1, Bondarenko N.A.1, Poveshchenko O.V.1, Kabakov A.V.1, Surovtseva M.A.1, Kim I.I.1, Kazakov O.V.1, Poveshchenko A.F.1
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Affiliations:
- Research Institute of Clinical and Experimental Lymphology —Branch of Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- Issue: Vol 165, No 1 (2018)
- Pages: 121-126
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240042
- DOI: https://doi.org/10.1007/s10517-018-4112-z
- ID: 240042
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Abstract
We studied the effect of intramuscular injections of bone marrow mesenchymal stromal cells on microcirculation parameters in an ischemic limb of Wistar rats. It was shown that transplantation of mesenchymal stem cells with or without erythropoietin stimulates angiogenesis in the ischemic zone. An essential role in angiogenesis stimulation is played by cytokines and growth factors.
About the authors
A. P. Lykov
Research Institute of Clinical and Experimental Lymphology —Branch of Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Author for correspondence.
Email: aplykov2@mail.ru
Russian Federation, Novosibirsk
N. A. Bondarenko
Research Institute of Clinical and Experimental Lymphology —Branch of Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: aplykov2@mail.ru
Russian Federation, Novosibirsk
O. V. Poveshchenko
Research Institute of Clinical and Experimental Lymphology —Branch of Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: aplykov2@mail.ru
Russian Federation, Novosibirsk
A. V. Kabakov
Research Institute of Clinical and Experimental Lymphology —Branch of Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: aplykov2@mail.ru
Russian Federation, Novosibirsk
M. A. Surovtseva
Research Institute of Clinical and Experimental Lymphology —Branch of Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: aplykov2@mail.ru
Russian Federation, Novosibirsk
I. I. Kim
Research Institute of Clinical and Experimental Lymphology —Branch of Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: aplykov2@mail.ru
Russian Federation, Novosibirsk
O. V. Kazakov
Research Institute of Clinical and Experimental Lymphology —Branch of Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: aplykov2@mail.ru
Russian Federation, Novosibirsk
A. F. Poveshchenko
Research Institute of Clinical and Experimental Lymphology —Branch of Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: aplykov2@mail.ru
Russian Federation, Novosibirsk
