Effect of Intramuscular Administration of Mesenchymal Stem Cells and Erythropoietin on Angiogenesis in Critical Limb Ischemia


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Аннотация

We studied the effect of intramuscular injections of bone marrow mesenchymal stromal cells on microcirculation parameters in an ischemic limb of Wistar rats. It was shown that transplantation of mesenchymal stem cells with or without erythropoietin stimulates angiogenesis in the ischemic zone. An essential role in angiogenesis stimulation is played by cytokines and growth factors.

Об авторах

A. Lykov

Research Institute of Clinical and Experimental Lymphology —Branch of Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences

Автор, ответственный за переписку.
Email: aplykov2@mail.ru
Россия, Novosibirsk

N. Bondarenko

Research Institute of Clinical and Experimental Lymphology —Branch of Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences

Email: aplykov2@mail.ru
Россия, Novosibirsk

O. Poveshchenko

Research Institute of Clinical and Experimental Lymphology —Branch of Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences

Email: aplykov2@mail.ru
Россия, Novosibirsk

A. Kabakov

Research Institute of Clinical and Experimental Lymphology —Branch of Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences

Email: aplykov2@mail.ru
Россия, Novosibirsk

M. Surovtseva

Research Institute of Clinical and Experimental Lymphology —Branch of Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences

Email: aplykov2@mail.ru
Россия, Novosibirsk

I. Kim

Research Institute of Clinical and Experimental Lymphology —Branch of Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences

Email: aplykov2@mail.ru
Россия, Novosibirsk

O. Kazakov

Research Institute of Clinical and Experimental Lymphology —Branch of Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences

Email: aplykov2@mail.ru
Россия, Novosibirsk

A. Poveshchenko

Research Institute of Clinical and Experimental Lymphology —Branch of Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences

Email: aplykov2@mail.ru
Россия, Novosibirsk


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