Effect of Intramuscular Administration of Mesenchymal Stem Cells and Erythropoietin on Angiogenesis in Critical Limb Ischemia


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We studied the effect of intramuscular injections of bone marrow mesenchymal stromal cells on microcirculation parameters in an ischemic limb of Wistar rats. It was shown that transplantation of mesenchymal stem cells with or without erythropoietin stimulates angiogenesis in the ischemic zone. An essential role in angiogenesis stimulation is played by cytokines and growth factors.

作者简介

A. Lykov

Research Institute of Clinical and Experimental Lymphology —Branch of Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences

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Email: aplykov2@mail.ru
俄罗斯联邦, Novosibirsk

N. Bondarenko

Research Institute of Clinical and Experimental Lymphology —Branch of Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences

Email: aplykov2@mail.ru
俄罗斯联邦, Novosibirsk

O. Poveshchenko

Research Institute of Clinical and Experimental Lymphology —Branch of Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences

Email: aplykov2@mail.ru
俄罗斯联邦, Novosibirsk

A. Kabakov

Research Institute of Clinical and Experimental Lymphology —Branch of Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences

Email: aplykov2@mail.ru
俄罗斯联邦, Novosibirsk

M. Surovtseva

Research Institute of Clinical and Experimental Lymphology —Branch of Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences

Email: aplykov2@mail.ru
俄罗斯联邦, Novosibirsk

I. Kim

Research Institute of Clinical and Experimental Lymphology —Branch of Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences

Email: aplykov2@mail.ru
俄罗斯联邦, Novosibirsk

O. Kazakov

Research Institute of Clinical and Experimental Lymphology —Branch of Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences

Email: aplykov2@mail.ru
俄罗斯联邦, Novosibirsk

A. Poveshchenko

Research Institute of Clinical and Experimental Lymphology —Branch of Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences

Email: aplykov2@mail.ru
俄罗斯联邦, Novosibirsk


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