Cell Death and Development of Fibrotic Alterations in Lung Granuloma of BALB/c Mice during Chronic BCG-Induced Granulomatosis

L. A. Cherdantseva; O. V. Potapova; T. V. Sharkova; A. M. Anikina; A. V. Kovner; A. V. Troitskii; V. A. Shkurupy

doi:10.1007/s10517-018-4096-8

Cell Death and Development of Fibrotic Alterations in Lung Granuloma of BALB/c Mice during Chronic BCG-Induced Granulomatosis

Authors: Cherdantseva L.A.¹, Potapova O.V.², Sharkova T.V.², Anikina A.M.¹, Kovner A.V.¹, Troitskii A.V.¹, Shkurupy V.A.³
Affiliations:
1. Research Institute of Experimental and Clinical Medicine
2. Optimum Medical Laboratory, Research-and-Educational Center
3. Novosibirsk State Medical University, Ministry of Health of the Russian Federation
Issue: Vol 165, No 1 (2018)
Pages: 48-51
Section: Microbiology and Immunology
URL: https://journals.rcsi.science/0007-4888/article/view/239967
DOI: https://doi.org/10.1007/s10517-018-4096-8
ID: 239967

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Abstract

Light microscopy, immunohistochemistry, and morphometric examinations established that cell death in lung granulomas of BCG-infected mice resulted mainly from activation of receptor-mediated apoptosis, which did not prevent the persistence of the causative agent in macrophages of the granulomas and promoted the formation of pronounced fibrosis in granulomas and pulmonary interstitium.