Cell Death and Development of Fibrotic Alterations in Lung Granuloma of BALB/c Mice during Chronic BCG-Induced Granulomatosis
- Авторлар: Cherdantseva L.1, Potapova O.2, Sharkova T.2, Anikina A.1, Kovner A.1, Troitskii A.1, Shkurupy V.3
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Мекемелер:
- Research Institute of Experimental and Clinical Medicine
- Optimum Medical Laboratory, Research-and-Educational Center
- Novosibirsk State Medical University, Ministry of Health of the Russian Federation
- Шығарылым: Том 165, № 1 (2018)
- Беттер: 48-51
- Бөлім: Microbiology and Immunology
- URL: https://journals.rcsi.science/0007-4888/article/view/239967
- DOI: https://doi.org/10.1007/s10517-018-4096-8
- ID: 239967
Дәйексөз келтіру
Аннотация
Light microscopy, immunohistochemistry, and morphometric examinations established that cell death in lung granulomas of BCG-infected mice resulted mainly from activation of receptor-mediated apoptosis, which did not prevent the persistence of the causative agent in macrophages of the granulomas and promoted the formation of pronounced fibrosis in granulomas and pulmonary interstitium.
Авторлар туралы
L. Cherdantseva
Research Institute of Experimental and Clinical Medicine
Хат алмасуға жауапты Автор.
Email: cherdanceff@yandex.ru
Ресей, Novosibirsk
O. Potapova
Optimum Medical Laboratory, Research-and-Educational Center
Email: cherdanceff@yandex.ru
Ресей, Sochi
T. Sharkova
Optimum Medical Laboratory, Research-and-Educational Center
Email: cherdanceff@yandex.ru
Ресей, Sochi
A. Anikina
Research Institute of Experimental and Clinical Medicine
Email: cherdanceff@yandex.ru
Ресей, Novosibirsk
A. Kovner
Research Institute of Experimental and Clinical Medicine
Email: cherdanceff@yandex.ru
Ресей, Novosibirsk
A. Troitskii
Research Institute of Experimental and Clinical Medicine
Email: cherdanceff@yandex.ru
Ресей, Novosibirsk
V. Shkurupy
Novosibirsk State Medical University, Ministry of Health of the Russian Federation
Email: cherdanceff@yandex.ru
Ресей, Novosibirsk