Cell Death and Development of Fibrotic Alterations in Lung Granuloma of BALB/c Mice during Chronic BCG-Induced Granulomatosis
- Authors: Cherdantseva L.A.1, Potapova O.V.2, Sharkova T.V.2, Anikina A.M.1, Kovner A.V.1, Troitskii A.V.1, Shkurupy V.A.3
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Affiliations:
- Research Institute of Experimental and Clinical Medicine
- Optimum Medical Laboratory, Research-and-Educational Center
- Novosibirsk State Medical University, Ministry of Health of the Russian Federation
- Issue: Vol 165, No 1 (2018)
- Pages: 48-51
- Section: Microbiology and Immunology
- URL: https://journals.rcsi.science/0007-4888/article/view/239967
- DOI: https://doi.org/10.1007/s10517-018-4096-8
- ID: 239967
Cite item
Abstract
Light microscopy, immunohistochemistry, and morphometric examinations established that cell death in lung granulomas of BCG-infected mice resulted mainly from activation of receptor-mediated apoptosis, which did not prevent the persistence of the causative agent in macrophages of the granulomas and promoted the formation of pronounced fibrosis in granulomas and pulmonary interstitium.
About the authors
L. A. Cherdantseva
Research Institute of Experimental and Clinical Medicine
Author for correspondence.
Email: cherdanceff@yandex.ru
Russian Federation, Novosibirsk
O. V. Potapova
Optimum Medical Laboratory, Research-and-Educational Center
Email: cherdanceff@yandex.ru
Russian Federation, Sochi
T. V. Sharkova
Optimum Medical Laboratory, Research-and-Educational Center
Email: cherdanceff@yandex.ru
Russian Federation, Sochi
A. M. Anikina
Research Institute of Experimental and Clinical Medicine
Email: cherdanceff@yandex.ru
Russian Federation, Novosibirsk
A. V. Kovner
Research Institute of Experimental and Clinical Medicine
Email: cherdanceff@yandex.ru
Russian Federation, Novosibirsk
A. V. Troitskii
Research Institute of Experimental and Clinical Medicine
Email: cherdanceff@yandex.ru
Russian Federation, Novosibirsk
V. A. Shkurupy
Novosibirsk State Medical University, Ministry of Health of the Russian Federation
Email: cherdanceff@yandex.ru
Russian Federation, Novosibirsk