Cell Death and Development of Fibrotic Alterations in Lung Granuloma of BALB/c Mice during Chronic BCG-Induced Granulomatosis
- Авторы: Cherdantseva L.1, Potapova O.2, Sharkova T.2, Anikina A.1, Kovner A.1, Troitskii A.1, Shkurupy V.3
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Учреждения:
- Research Institute of Experimental and Clinical Medicine
- Optimum Medical Laboratory, Research-and-Educational Center
- Novosibirsk State Medical University, Ministry of Health of the Russian Federation
- Выпуск: Том 165, № 1 (2018)
- Страницы: 48-51
- Раздел: Microbiology and Immunology
- URL: https://journals.rcsi.science/0007-4888/article/view/239967
- DOI: https://doi.org/10.1007/s10517-018-4096-8
- ID: 239967
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Аннотация
Light microscopy, immunohistochemistry, and morphometric examinations established that cell death in lung granulomas of BCG-infected mice resulted mainly from activation of receptor-mediated apoptosis, which did not prevent the persistence of the causative agent in macrophages of the granulomas and promoted the formation of pronounced fibrosis in granulomas and pulmonary interstitium.
Об авторах
L. Cherdantseva
Research Institute of Experimental and Clinical Medicine
Автор, ответственный за переписку.
Email: cherdanceff@yandex.ru
Россия, Novosibirsk
O. Potapova
Optimum Medical Laboratory, Research-and-Educational Center
Email: cherdanceff@yandex.ru
Россия, Sochi
T. Sharkova
Optimum Medical Laboratory, Research-and-Educational Center
Email: cherdanceff@yandex.ru
Россия, Sochi
A. Anikina
Research Institute of Experimental and Clinical Medicine
Email: cherdanceff@yandex.ru
Россия, Novosibirsk
A. Kovner
Research Institute of Experimental and Clinical Medicine
Email: cherdanceff@yandex.ru
Россия, Novosibirsk
A. Troitskii
Research Institute of Experimental and Clinical Medicine
Email: cherdanceff@yandex.ru
Россия, Novosibirsk
V. Shkurupy
Novosibirsk State Medical University, Ministry of Health of the Russian Federation
Email: cherdanceff@yandex.ru
Россия, Novosibirsk
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