Email this article Studying the General Toxicity and Cumulative Properties of a Radiopharmaceutical Nanocolloid, 99mTc-Al2O3
- Authors: Varlamova N.V.1, Churin A.A.2, Fomina T.I.2, Ermolaeva L.A.2, Vetoshkina T.V.2, Dubskaya T.Y.2, Lamzina T.Y.2, Fedorova E.P.2, Neupokoeva O.V.2, Skuridin V.S.1, Nesterov E.A.1, Larionova L.A.1, Chernov V.I.1,3
-
Affiliations:
- Laboratory No. 3, Physicotechnical Institute, Tomsk Polytechnic University
- Laboratory of Drug Toxicology, E. D. Goldberg Research, Institute of Pharmacology and Regenerative Medicine
- Laboratory for Radionuclide Methods of Study, Tomsk Research Institute of Oncology
- Issue: Vol 161, No 3 (2016)
- Pages: 371-373
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237426
- DOI: https://doi.org/10.1007/s10517-016-3416-0
- ID: 237426
Cite item
Open Access
Access granted
Subscription Access
Abstract
We studied toxicity of a new Russian radiopharmaceutical Nanocolloid, 99mTc-Al2O3. Tests for acute toxicity showed that this agent belongs to a class of moderate-toxicity substances and does not have cumulative properties. The evaluation of subchronic toxicity after subcutaneous injection of this product to rats (0.04, 0.2, and 0.4 ml/kg) and rabbits (0.02 and 0.2 ml/kg) for 7 days did not reveal changes in the general state, temperature, body weight, indices of the peripheral blood and bone marrow, functions of the heart, liver, kidneys, and nervous system, and morphological characteristics of the internal organs in animals. The drug does not produce a local irritant effect.
About the authors
N. V. Varlamova
Laboratory No. 3, Physicotechnical Institute, Tomsk Polytechnic University
Author for correspondence.
Email: varlamova@tpu.ru
Russian Federation, Tomsk
A. A. Churin
Laboratory of Drug Toxicology, E. D. Goldberg Research, Institute of Pharmacology and Regenerative Medicine
Email: varlamova@tpu.ru
Russian Federation, Tomsk
T. I. Fomina
Laboratory of Drug Toxicology, E. D. Goldberg Research, Institute of Pharmacology and Regenerative Medicine
Email: varlamova@tpu.ru
Russian Federation, Tomsk
L. A. Ermolaeva
Laboratory of Drug Toxicology, E. D. Goldberg Research, Institute of Pharmacology and Regenerative Medicine
Email: varlamova@tpu.ru
Russian Federation, Tomsk
T. V. Vetoshkina
Laboratory of Drug Toxicology, E. D. Goldberg Research, Institute of Pharmacology and Regenerative Medicine
Email: varlamova@tpu.ru
Russian Federation, Tomsk
T. Yu. Dubskaya
Laboratory of Drug Toxicology, E. D. Goldberg Research, Institute of Pharmacology and Regenerative Medicine
Email: varlamova@tpu.ru
Russian Federation, Tomsk
T. Yu. Lamzina
Laboratory of Drug Toxicology, E. D. Goldberg Research, Institute of Pharmacology and Regenerative Medicine
Email: varlamova@tpu.ru
Russian Federation, Tomsk
E. P. Fedorova
Laboratory of Drug Toxicology, E. D. Goldberg Research, Institute of Pharmacology and Regenerative Medicine
Email: varlamova@tpu.ru
Russian Federation, Tomsk
O. V. Neupokoeva
Laboratory of Drug Toxicology, E. D. Goldberg Research, Institute of Pharmacology and Regenerative Medicine
Email: varlamova@tpu.ru
Russian Federation, Tomsk
V. S. Skuridin
Laboratory No. 3, Physicotechnical Institute, Tomsk Polytechnic University
Email: varlamova@tpu.ru
Russian Federation, Tomsk
E. A. Nesterov
Laboratory No. 3, Physicotechnical Institute, Tomsk Polytechnic University
Email: varlamova@tpu.ru
Russian Federation, Tomsk
L. A. Larionova
Laboratory No. 3, Physicotechnical Institute, Tomsk Polytechnic University
Email: varlamova@tpu.ru
Russian Federation, Tomsk
V. I. Chernov
Laboratory No. 3, Physicotechnical Institute, Tomsk Polytechnic University; Laboratory for Radionuclide Methods of Study, Tomsk Research Institute of Oncology
Email: varlamova@tpu.ru
Russian Federation, Tomsk; Tomsk
